A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects

Notch signaling is a conserved pathway that converts extracellular receptor-ligand interactions into changes in gene expression via a single transcription factor (CBF1/RBPJ in mammals; Su(H) in Drosophila). In humans, RBPJ variants have been linked to Adams-Oliver syndrome (AOS), a rare autosomal do...

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Detalles Bibliográficos
Autores principales: Gagliani, Ellen K., Gutzwiller, Lisa M., Kuang, Yi, Odaka, Yoshinobu, Hoffmeister, Phillipp, Hauff, Stefanie, Turkiewicz, Aleksandra, Harding-Theobald, Emily, Dolph, Patrick J., Borggrefe, Tilman, Oswald, Franz, Gebelein, Brian, Kovall, Rhett A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398005/
https://www.ncbi.nlm.nih.gov/pubmed/35951645
http://dx.doi.org/10.1371/journal.pgen.1010335

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