Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity

BACKGROUND: Coding variation in the Leucine rich repeat kinase 2 gene linked to Parkinson’s disease (PD) promotes enhanced activity of the encoded LRRK2 kinase, particularly with respect to autophosphorylation at S1292 and/or phosphorylation of the heterologous substrate RAB10. OBJECTIVE: To determi...

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Detalles Bibliográficos
Autores principales: Fernández, Belén, Chittoor-Vinod, Vinita G., Kluss, Jillian H., Kelly, Kaela, Bryant, Nicole, Nguyen, An Phu Tran, Bukhari, Syed A., Smith, Nathan, Lara Ordóñez, Antonio Jesús, Fdez, Elena, Chartier-Harlin, Marie-Christine, Montine, Thomas J., Wilson, Mark A., Moore, Darren J., West, Andrew B., Cookson, Mark R., Nichols, R. Jeremy, Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Michael J. Fox Foundation – Replication Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398093/
https://www.ncbi.nlm.nih.gov/pubmed/35599495
http://dx.doi.org/10.3233/JPD-213128

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