Cargando…

Anti-CD19 CAR T Cells That Secrete a Biparatopic Anti-CLEC12A Bridging Protein Have Potent Activity Against Highly Aggressive Acute Myeloid Leukemia In Vitro and In Vivo

Refractory acute myeloid leukemia (AML) remains an incurable malignancy despite the clinical use of novel targeted therapies, new antibody-based therapies, and cellular therapeutics. Here, we describe the preclinical development of a novel cell therapy that targets the antigen CLEC12A with a biparat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rennert, Paul D., Dufort, Fay J., Su, Lihe, Sanford, Tom, Birt, Alyssa, Wu, Lan, Lobb, Roy R., Ambrose, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Models and Technologies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398100/ https://www.ncbi.nlm.nih.gov/pubmed/34253594 http://dx.doi.org/10.1158/1535-7163.MCT-20-1030

Ejemplares similares

Anti-CD19 CAR T cells potently redirected to kill solid tumor cells
por: Ambrose, Christine, et al.
Publicado: (2021)

CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma
por: Su, Lihe, et al.
Publicado: (2022)

B7-H3 Specific CAR T Cells for the Naturally Occurring, Spontaneous Canine Sarcoma Model
por: Zhang, Shihong, et al.
Publicado: (2022)

FGFR4-Targeted Chimeric Antigen Receptors Combined with Anti-Myeloid Polypharmacy Effectively Treat Orthotopic Rhabdomyosarcoma
por: Sullivan, Peter M., et al.
Publicado: (2022)

Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory
por: Martinez-Velez, Naiara, et al.
Publicado: (2022)

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction
por: Durrant, David E., et al.
Publicado: (2021)

Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing
por: Inoue, Tomoyoshi, et al.
Publicado: (2021)

Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling
por: Surman, Deborah R., et al.
Publicado: (2021)

Novel Group C Oncolytic Adenoviruses Carrying a miRNA Inhibitor Demonstrate Enhanced Oncolytic Activity In Vitro and In Vivo
por: Doerner, Johannes, et al.
Publicado: (2022)

CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization
por: Werr, Lisa, et al.
Publicado: (2022)

Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo
por: Trovato, Francesco, et al.
Publicado: (2023)

Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation–Positive, MET-Amplified Non–Small Cell Lung Cancer Model
por: Jones, Rhys D.O., et al.
Publicado: (2023)

An Oncolytic Poxvirus Encoding hNIS, Shows Antitumor Efficacy and Allows Tumor Imaging in a Liver Cancer Model
por: Chaurasiya, Shyambabu, et al.
Publicado: (2023)

Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer
por: Lee, Catherine, et al.
Publicado: (2023)

A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2(+) Solid Cancer
por: Hombach, Andreas A., et al.
Publicado: (2023)

JSKN003, A NOVEL BIPARATOPIC ANTI-HER2 ANTIBODY-DRUG CONJUGATE, EXHIBITS POTENT ANTITUMOR EFFICACY
por: Wang, Pilin, et al.
Publicado: (2023)

Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody
por: Oganesyan, Vaheh, et al.
Publicado: (2018)

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action
por: Kast, Florian, et al.
Publicado: (2021)

Bp-Bs, a Novel T-cell Engaging Bispecific Antibody with Biparatopic Her2 Binding, Has Potent Anti-tumor Activities
por: Liu, Jiayu, et al.
Publicado: (2019)

Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy
por: Godar, Marie, et al.
Publicado: (2016)

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity
por: Weisser, Nina E., et al.
Publicado: (2023)

2D-QSAR model development and analysis on variant groups of anti-tuberculosis drugs
por: Dwivedi, Neeraja, et al.
Publicado: (2011)

Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody
por: Cheng, Jackie, et al.
Publicado: (2020)

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains
por: Chen, Chuan, et al.
Publicado: (2022)

A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms
por: Stefano, James E., et al.
Publicado: (2021)

A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models
por: Fan, Jiansheng, et al.
Publicado: (2021)

Enhancement of Polymeric Immunoglobulin Receptor Transcytosis by Biparatopic VHH
por: Emmerson, Chris D., et al.
Publicado: (2011)

Classification of anti hepatitis peptides using Support Vector Machine with hybrid Ant Colony OptimizationThe Luxembourg database of trichothecene type B F. graminearum and F. culmorum producers
por: Mishra, Gunjan, et al.
Publicado: (2016)

Extracorporeal Perfusion of Vascularized Composite Tissues: The Bridging Role of an Emerging Technology in Reconstructive Microsurgery
por: Bengur, Fuat Baris, et al.
Publicado: (2022)

Integrating spatially explicit indices of abundance and habitat quality: an applied example for greater sage‐grouse management
por: Coates, Peter S., et al.
Publicado: (2015)

TMOD-05. GENOME-WIDE DNA METHYLATION PROFILE: A POWERFUL STRATEGY TO RECAPITULATE HETEROGENEITY OF PEDIATRIC BRAIN TUMORS IN PRIMARY CELL LINES
por: Pedace, Lucia, et al.
Publicado: (2021)

TMOD-06. LOSS OF DICER COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE METASTATIC MEDULLOBLASTOMA
por: Alcantara Llaguno, Sheila, et al.
Publicado: (2021)

Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities
por: Assimopoulos, Stephania, et al.
Publicado: (2022)

Altered medial prefrontal cortex and dorsal raphé activity predict genotype and correlate with abnormal learning behavior in a mouse model of autism‐associated 2p16.3 deletion
por: Hughes, Rebecca B., et al.
Publicado: (2022)

Reduced brain volume and white matter alterations in Shank3‐deficient rats
por: Golden, Carla E. M., et al.
Publicado: (2021)

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection
por: Akiba, Hiroki, et al.
Publicado: (2023)

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells
por: Schütze, Kerstin, et al.
Publicado: (2018)

Treatment of aggressive T-cell lymphoma/leukemia with anti-CD4 CAR T cells
por: Feng, Jia, et al.
Publicado: (2022)

Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4(+) Cancers
por: Cano-Garrido, Olivia, et al.
Publicado: (2021)

Anti-Matter - Tommy Eriksson
por: CERN. Geneva
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_sr73u1l7mieko4t2bh9snle1fs