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Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Although several ATR inhibitors are in development, there are unresolved questions regarding their differential potency, molecular signatures of patients with cancer for predicting activity, and most effective therapeutic combinations. Here, we elucidate how to improve ATR-based chemotherapy with th...

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Detalles Bibliográficos
Autores principales:	Jo, Ukhyun, Senatorov, Ilya S., Zimmermann, Astrid, Saha, Liton Kumar, Murai, Yasuhisa, Kim, Se Hyun, Rajapakse, Vinodh N., Elloumi, Fathi, Takahashi, Nobuyuki, Schultz, Christopher W., Thomas, Anish, Zenke, Frank T., Pommier, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Small Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398135/ https://www.ncbi.nlm.nih.gov/pubmed/34045232 http://dx.doi.org/10.1158/1535-7163.MCT-20-1026

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