Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas

The pro-survival MCL1 protein is overexpressed in many cancers, including B-cell non–Hodgkin lymphomas (B-NHL). S63845 is a highly specific inhibitor of MCL1. We analyzed mechanisms of sensitivity/resistance to S63845 in preclinical models of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphom...

Descripción completa

Detalles Bibliográficos
Autores principales: Klanova, Magdalena, Kazantsev, Dmitry, Pokorna, Eva, Zikmund, Tomas, Karolova, Jana, Behounek, Matej, Renesova, Nicol, Sovilj, Dana, Kelemen, Cristina D., Helman, Karel, Jaksa, Radek, Havranek, Ondrej, Andera, Ladislav, Trneny, Marek, Klener, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398137/
https://www.ncbi.nlm.nih.gov/pubmed/34728569
http://dx.doi.org/10.1158/1535-7163.MCT-21-0511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398137/
https://www.ncbi.nlm.nih.gov/pubmed/34728569
http://dx.doi.org/10.1158/1535-7163.MCT-21-0511

Ejemplares similares