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Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas

The pro-survival MCL1 protein is overexpressed in many cancers, including B-cell non–Hodgkin lymphomas (B-NHL). S63845 is a highly specific inhibitor of MCL1. We analyzed mechanisms of sensitivity/resistance to S63845 in preclinical models of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphom...

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Detalles Bibliográficos
Autores principales:	Klanova, Magdalena, Kazantsev, Dmitry, Pokorna, Eva, Zikmund, Tomas, Karolova, Jana, Behounek, Matej, Renesova, Nicol, Sovilj, Dana, Kelemen, Cristina D., Helman, Karel, Jaksa, Radek, Havranek, Ondrej, Andera, Ladislav, Trneny, Marek, Klener, Pavel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Small Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398137/ https://www.ncbi.nlm.nih.gov/pubmed/34728569 http://dx.doi.org/10.1158/1535-7163.MCT-21-0511

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