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Recombinant Newcastle Disease Virus Immunotherapy Drives Oncolytic Effects and Durable Systemic Antitumor Immunity

A recombinant Newcastle Disease Virus (NDV), encoding either a human (NDVhuGM-CSF, MEDI5395) or murine (NDVmuGM-CSF) GM-CSF transgene, combined broad oncolytic activity with the ability to significantly modulate genes related to immune functionality in human tumor cells. Replication in murine tumor...

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Detalles Bibliográficos
Autores principales:	Harper, James, Burke, Shannon, Travers, Jon, Rath, Nicola, Leinster, Andrew, Navarro, Christel, Franks, Ruth, Leyland, Rebecca, Mulgrew, Kathy, McGlinchey, Kelly, Brown, Lee, Dovedi, Simon J., Koopmann, Jens-Oliver, Durham, Nicholas M., Cheng, Xing, Jin, Hong, Eyles, Jim, Wilkinson, Robert W., Carroll, Danielle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Large Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398146/ https://www.ncbi.nlm.nih.gov/pubmed/34224361 http://dx.doi.org/10.1158/1535-7163.MCT-20-0902

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