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Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8(+) T-cell Responses

Lymph node (LN)–resident lymphatic endothelial cells (LEC) mediate peripheral tolerance by self-antigen presentation on MHC-I and constitutive expression of T-cell inhibitory molecules, including PD-L1 (CD274). Tumor-associated LECs also upregulate PD-L1, but the specific role of lymphatic PD-L1 in...

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Detalles Bibliográficos
Autores principales:	Cousin, Nikola, Cap, Stefan, Dihr, Manuel, Tacconi, Carlotta, Detmar, Michael, Dieterich, Lothar C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Tumor Biology and Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398148/ https://www.ncbi.nlm.nih.gov/pubmed/34099493 http://dx.doi.org/10.1158/0008-5472.CAN-21-0633

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