Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199

Death receptor 5 (DR5) is an attractive target for cancer therapy due to its broad upregulated expression in multiple cancers and ability to directly induce apoptosis. Though anti-DR5 IgG antibodies have been evaluated in clinical trials, limited efficacy has been attributed to insufficient receptor...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Beatrice T., Kothambawala, Tasnim, Wang, Ling, Matthew, Thomas J., Calhoun, Susan E., Saini, Avneesh K., Kotturi, Maya F., Hernandez, Genevive, Humke, Eric W., Peterson, Marvin S., Sinclair, Angus M., Keyt, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Large Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398157/
https://www.ncbi.nlm.nih.gov/pubmed/34711645
http://dx.doi.org/10.1158/1535-7163.MCT-20-1132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398157/
https://www.ncbi.nlm.nih.gov/pubmed/34711645
http://dx.doi.org/10.1158/1535-7163.MCT-20-1132

Ejemplares similares