Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity

The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required for cellular proliferation. Dysregulation of PRMT5 is associated...

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Detalles Bibliográficos
Autores principales: Brehmer, Dirk, Beke, Lijs, Wu, Tongfei, Millar, Hillary J., Moy, Christopher, Sun, Weimei, Mannens, Geert, Pande, Vineet, Boeckx, An, van Heerde, Erika, Nys, Thomas, Gustin, Emmanuel M., Verbist, Bie, Zhou, Longen, Fan, Yue, Bhargava, Vipul, Safabakhsh, Pegah, Vinken, Petra, Verhulst, Tinne, Gilbert, Angelique, Rai, Sumit, Graubert, Timothy A., Pastore, Friederike, Fiore, Danilo, Gu, Junchen, Johnson, Amy, Philippar, Ulrike, Morschhäuser, Barbara, Walker, David, De Lange, Desiree, Keersmaekers, Vikki, Viellevoye, Marcel, Diels, Gaston, Schepens, Wim, Thuring, Jan Willem, Meerpoel, Lieven, Packman, Kathryn, Lorenzi, Matthew V., Laquerre, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
MCT First Disclosures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398174/
https://www.ncbi.nlm.nih.gov/pubmed/34583982
http://dx.doi.org/10.1158/1535-7163.MCT-21-0367

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