Genome‐wide analyses of PAM‐relaxed Cas9 genome editors reveal substantial off‐target effects by ABE8e in rice

PAM‐relaxed Cas9 nucleases, cytosine base editors and adenine base editors are promising tools for precise genome editing in plants. However, their genome‐wide off‐target effects are largely unexplored. Here, we conduct whole‐genome sequencing (WGS) analyses of transgenic plants edited by xCas9, Cas...

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Detalles Bibliográficos
Autores principales: Wu, Yuechao, Ren, Qiurong, Zhong, Zhaohui, Liu, Guanqing, Han, Yangshuo, Bao, Yu, Liu, Li, Xiang, Shuyue, Liu, Shuo, Tang, Xu, Zhou, Jianping, Zheng, Xuelian, Sretenovic, Simon, Zhang, Tao, Qi, Yiping, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398351/
https://www.ncbi.nlm.nih.gov/pubmed/35524459
http://dx.doi.org/10.1111/pbi.13838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398351/
https://www.ncbi.nlm.nih.gov/pubmed/35524459
http://dx.doi.org/10.1111/pbi.13838

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