Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. However, little attention has been paid to the characteristics of the immune microenvironment in AM. Therefore, in this study, we collected clinical samples from Chinese pati...

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Autores principales: He, Zan, Xin, Zijuan, Yang, Qiong, Wang, Chen, Li, Meng, Rao, Wei, Du, Zhimin, Bai, Jia, Guo, Zixuan, Ruan, Xiuyan, Zhang, Zhaojun, Fang, Xiangdong, Zhao, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398445/
https://www.ncbi.nlm.nih.gov/pubmed/35894206
http://dx.doi.org/10.7554/eLife.78616
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author He, Zan
Xin, Zijuan
Yang, Qiong
Wang, Chen
Li, Meng
Rao, Wei
Du, Zhimin
Bai, Jia
Guo, Zixuan
Ruan, Xiuyan
Zhang, Zhaojun
Fang, Xiangdong
Zhao, Hua
author_facet He, Zan
Xin, Zijuan
Yang, Qiong
Wang, Chen
Li, Meng
Rao, Wei
Du, Zhimin
Bai, Jia
Guo, Zixuan
Ruan, Xiuyan
Zhang, Zhaojun
Fang, Xiangdong
Zhao, Hua
author_sort He, Zan
collection PubMed
description Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. However, little attention has been paid to the characteristics of the immune microenvironment in AM. Therefore, in this study, we collected clinical samples from Chinese patients with AM and conducted single-cell RNA sequencing to analyze the heterogeneity of its tumor microenvironments (TMEs) and the molecular regulatory network. Our analysis revealed that genes, such as TWIST1, EREG, TNFRSF9, and CTGF could drive the deregulation of various TME components. The molecular interaction relationships between TME cells, such as MIF-CD44 and TNFSF9-TNFRSF9, might be an attractive target for developing novel immunotherapeutic agents.
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spelling pubmed-93984452022-08-24 Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments He, Zan Xin, Zijuan Yang, Qiong Wang, Chen Li, Meng Rao, Wei Du, Zhimin Bai, Jia Guo, Zixuan Ruan, Xiuyan Zhang, Zhaojun Fang, Xiangdong Zhao, Hua eLife Cancer Biology Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. However, little attention has been paid to the characteristics of the immune microenvironment in AM. Therefore, in this study, we collected clinical samples from Chinese patients with AM and conducted single-cell RNA sequencing to analyze the heterogeneity of its tumor microenvironments (TMEs) and the molecular regulatory network. Our analysis revealed that genes, such as TWIST1, EREG, TNFRSF9, and CTGF could drive the deregulation of various TME components. The molecular interaction relationships between TME cells, such as MIF-CD44 and TNFSF9-TNFRSF9, might be an attractive target for developing novel immunotherapeutic agents. eLife Sciences Publications, Ltd 2022-07-27 /pmc/articles/PMC9398445/ /pubmed/35894206 http://dx.doi.org/10.7554/eLife.78616 Text en © 2022, He, Xin, Yang et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cancer Biology
He, Zan
Xin, Zijuan
Yang, Qiong
Wang, Chen
Li, Meng
Rao, Wei
Du, Zhimin
Bai, Jia
Guo, Zixuan
Ruan, Xiuyan
Zhang, Zhaojun
Fang, Xiangdong
Zhao, Hua
Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
title Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
title_full Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
title_fullStr Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
title_full_unstemmed Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
title_short Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
title_sort mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398445/
https://www.ncbi.nlm.nih.gov/pubmed/35894206
http://dx.doi.org/10.7554/eLife.78616
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