AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

Expression of the AR splice variant, androgen receptor variant 7 (AR-V7), in prostate cancer is correlated with poor patient survival and resistance to AR targeted therapies and taxanes. Currently, there is no specific inhibitor of AR-V7, while the molecular mechanisms regulating its biological func...

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Detalles Bibliográficos
Autores principales: Kim, Seaho, Au, CheukMan C, Jamalruddin, Mohd Azrin Bin, Abou-Ghali, Naira Essam, Mukhtar, Eiman, Portella, Luigi, Berger, Adeline, Worroll, Daniel, Vatsa, Prerna, Rickman, David S, Nanus, David M, Giannakakou, Paraskevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398446/
https://www.ncbi.nlm.nih.gov/pubmed/35848798
http://dx.doi.org/10.7554/eLife.73396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398446/
https://www.ncbi.nlm.nih.gov/pubmed/35848798
http://dx.doi.org/10.7554/eLife.73396

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