Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity

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The current coronavirus disease 2019 (COVID-19) pandemic highlights the need for broad-spectrum antiviral therapeutics. Here we describe a new class of self-assembling immunostimulatory short duplex RNAs that potently induce production of type I and type III interferon (IFN-I and IFN-III). These RNA...

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Detalles Bibliográficos
Autores principales: Si, Longlong, Bai, Haiqing, Oh, Crystal Yuri, Jiang, Amanda, Hong, Fan, Zhang, Tian, Ye, Yongxin, Jordan, Tristan X., Logue, James, McGrath, Marisa, Belgur, Chaitra, Calderon, Karina, Nurani, Atiq, Cao, Wuji, Carlson, Kenneth E., Prantil-Baun, Rachelle, Gygi, Steven P., Yang, Dong, Jonsson, Colleen B., tenOever, Benjamin R., Frieman, Matthew, Ingber, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398551/
https://www.ncbi.nlm.nih.gov/pubmed/36032397
http://dx.doi.org/10.1016/j.omtn.2022.08.031

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