Severe COVID-19 increases the risk of schizophrenia

The coronavirus SARS-CoV-2 invades the central nervous system, impacting the mental health of COVID-19 patients. We performed a two-sample Mendelian randomization analysis to assess the potential causal effects of COVID-19 on schizophrenia. Our analysis indicated that genetic liability to hospitaliz...

Descripción completa

Detalles Bibliográficos
Autores principales: Baranova, Ancha, Cao, Hongbao, Zhang, Fuquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398553/
https://www.ncbi.nlm.nih.gov/pubmed/36037742
http://dx.doi.org/10.1016/j.psychres.2022.114809
_version_ 1784772347995095040
author Baranova, Ancha
Cao, Hongbao
Zhang, Fuquan
author_facet Baranova, Ancha
Cao, Hongbao
Zhang, Fuquan
author_sort Baranova, Ancha
collection PubMed
description The coronavirus SARS-CoV-2 invades the central nervous system, impacting the mental health of COVID-19 patients. We performed a two-sample Mendelian randomization analysis to assess the potential causal effects of COVID-19 on schizophrenia. Our analysis indicated that genetic liability to hospitalized COVID-19 was associated with an increased risk for schizophrenia (OR: 1.11, 95% CI: 1.02−1.20, P = 0.013). However, genetic liability to SARS-CoV-2 infection was not associated with the risk of schizophrenia (1.06, 0.83−1.37, P = 0.643). Severe COVID-19 was associated with an 11% increased risk for schizophrenia, suggesting that schizophrenia should be assessed as one of the post-COVID-19 sequelae.
format Online
Article
Text
id pubmed-9398553
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-93985532022-08-24 Severe COVID-19 increases the risk of schizophrenia Baranova, Ancha Cao, Hongbao Zhang, Fuquan Psychiatry Res Short Communication The coronavirus SARS-CoV-2 invades the central nervous system, impacting the mental health of COVID-19 patients. We performed a two-sample Mendelian randomization analysis to assess the potential causal effects of COVID-19 on schizophrenia. Our analysis indicated that genetic liability to hospitalized COVID-19 was associated with an increased risk for schizophrenia (OR: 1.11, 95% CI: 1.02−1.20, P = 0.013). However, genetic liability to SARS-CoV-2 infection was not associated with the risk of schizophrenia (1.06, 0.83−1.37, P = 0.643). Severe COVID-19 was associated with an 11% increased risk for schizophrenia, suggesting that schizophrenia should be assessed as one of the post-COVID-19 sequelae. Elsevier B.V. 2022-11 2022-08-24 /pmc/articles/PMC9398553/ /pubmed/36037742 http://dx.doi.org/10.1016/j.psychres.2022.114809 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Baranova, Ancha
Cao, Hongbao
Zhang, Fuquan
Severe COVID-19 increases the risk of schizophrenia
title Severe COVID-19 increases the risk of schizophrenia
title_full Severe COVID-19 increases the risk of schizophrenia
title_fullStr Severe COVID-19 increases the risk of schizophrenia
title_full_unstemmed Severe COVID-19 increases the risk of schizophrenia
title_short Severe COVID-19 increases the risk of schizophrenia
title_sort severe covid-19 increases the risk of schizophrenia
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398553/
https://www.ncbi.nlm.nih.gov/pubmed/36037742
http://dx.doi.org/10.1016/j.psychres.2022.114809
work_keys_str_mv AT baranovaancha severecovid19increasestheriskofschizophrenia
AT caohongbao severecovid19increasestheriskofschizophrenia
AT zhangfuquan severecovid19increasestheriskofschizophrenia

Ejemplares similares