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Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles

BACKGROUND: Helicobacter pylori (HP) is a causative factor for several gastrointestinal diseases. A HP seropositive antibody titer (i.e., ≥10 U/mL), a threshold indicating an HP infection, is known to be associated with changes in lipid metabolism. There is evidence that HP infection can be found in...

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Autores principales: Lu, Jun, Van Hoang, Dong, Hayashi, Yuko, Hashimoto, Makiko, Kubo, Sachiko, Kajio, Hiroshi, Mizoue, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398768/
https://www.ncbi.nlm.nih.gov/pubmed/36017395
http://dx.doi.org/10.1155/2022/9984255
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author Lu, Jun
Van Hoang, Dong
Hayashi, Yuko
Hashimoto, Makiko
Kubo, Sachiko
Kajio, Hiroshi
Mizoue, Tetsuya
author_facet Lu, Jun
Van Hoang, Dong
Hayashi, Yuko
Hashimoto, Makiko
Kubo, Sachiko
Kajio, Hiroshi
Mizoue, Tetsuya
author_sort Lu, Jun
collection PubMed
description BACKGROUND: Helicobacter pylori (HP) is a causative factor for several gastrointestinal diseases. A HP seropositive antibody titer (i.e., ≥10 U/mL), a threshold indicating an HP infection, is known to be associated with changes in lipid metabolism. There is evidence that HP infection can be found in some individuals with HP antibody titer of between 3 and 9.9 U/mL (termed as “negative-high titer”). However, it is unknown about the relationship between HP negative-high titer and lipid metabolism. The present study aimed to quantify the association between HP negative-high antibody titer and lipid profiles. MATERIALS AND METHODS: We surveyed 2,478 people who underwent a Ningen Dock examination and had serological HP antibody data, from May 2016 to December 2020 at National Center for Global Health and Medicine, Tokyo, Japan. Multiple regression models were used to quantify the association between HP antibody titer and serum lipid levels. RESULTS: The adjusted odds ratio (95% confidence interval [CI]) for dyslipidemia in HP negative-high and positive titer was 1.24 (0.96, 1.79) and 1.36 (1.10, 1.68), respectively, compared with HP negative-low titer; p trend =0.005. The adjusted mean (95% CI) of high-density lipoprotein cholesterol (HDL-C) in HP negative-low, negative-high, and positive titer was 58.78 (57.86–59.71), 55.30 (53.70–56.91), and 53.76 (52.90–54.63) mg/dL, respectively; p trend <0.001. Higher HP antibody titers were also associated with higher ratio of low-density lipoprotein cholesterol (LDL-C) to HDL-C, but not triglycerides, or total cholesterols. CONCLUSION: The present cross-sectional study suggests that a HP negative-high antibody titer may be associated with dyslipidemia, HDL-C, and LDL-C to HDL-C ratio among Japanese Ningen Dock's participants.
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spelling pubmed-93987682022-08-24 Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles Lu, Jun Van Hoang, Dong Hayashi, Yuko Hashimoto, Makiko Kubo, Sachiko Kajio, Hiroshi Mizoue, Tetsuya Biomed Res Int Research Article BACKGROUND: Helicobacter pylori (HP) is a causative factor for several gastrointestinal diseases. A HP seropositive antibody titer (i.e., ≥10 U/mL), a threshold indicating an HP infection, is known to be associated with changes in lipid metabolism. There is evidence that HP infection can be found in some individuals with HP antibody titer of between 3 and 9.9 U/mL (termed as “negative-high titer”). However, it is unknown about the relationship between HP negative-high titer and lipid metabolism. The present study aimed to quantify the association between HP negative-high antibody titer and lipid profiles. MATERIALS AND METHODS: We surveyed 2,478 people who underwent a Ningen Dock examination and had serological HP antibody data, from May 2016 to December 2020 at National Center for Global Health and Medicine, Tokyo, Japan. Multiple regression models were used to quantify the association between HP antibody titer and serum lipid levels. RESULTS: The adjusted odds ratio (95% confidence interval [CI]) for dyslipidemia in HP negative-high and positive titer was 1.24 (0.96, 1.79) and 1.36 (1.10, 1.68), respectively, compared with HP negative-low titer; p trend =0.005. The adjusted mean (95% CI) of high-density lipoprotein cholesterol (HDL-C) in HP negative-low, negative-high, and positive titer was 58.78 (57.86–59.71), 55.30 (53.70–56.91), and 53.76 (52.90–54.63) mg/dL, respectively; p trend <0.001. Higher HP antibody titers were also associated with higher ratio of low-density lipoprotein cholesterol (LDL-C) to HDL-C, but not triglycerides, or total cholesterols. CONCLUSION: The present cross-sectional study suggests that a HP negative-high antibody titer may be associated with dyslipidemia, HDL-C, and LDL-C to HDL-C ratio among Japanese Ningen Dock's participants. Hindawi 2022-08-16 /pmc/articles/PMC9398768/ /pubmed/36017395 http://dx.doi.org/10.1155/2022/9984255 Text en Copyright © 2022 Jun Lu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lu, Jun
Van Hoang, Dong
Hayashi, Yuko
Hashimoto, Makiko
Kubo, Sachiko
Kajio, Hiroshi
Mizoue, Tetsuya
Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles
title Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles
title_full Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles
title_fullStr Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles
title_full_unstemmed Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles
title_short Negative-High Titer of Helicobacter pylori Antibody and Lipid Profiles
title_sort negative-high titer of helicobacter pylori antibody and lipid profiles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398768/
https://www.ncbi.nlm.nih.gov/pubmed/36017395
http://dx.doi.org/10.1155/2022/9984255
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