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Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East
This study aimed to assess the risk factors for COVID-19 mortality among hospitalized patients in Jordan. All COVID-19 patients admitted to a tertiary hospital in Jordan from September 20, 2020, to August 8, 2021, were included in this study. Demographics, clinical characteristics, comorbidities, an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398873/ https://www.ncbi.nlm.nih.gov/pubmed/36072822 http://dx.doi.org/10.1155/2022/9617319 |
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author | Karasneh, Reema A. Khassawneh, Basheer Y. Al-Azzam, Sayer Al-Mistarehi, Abdel-Hameed Lattyak, William J. Aldiab, Motasem Kabbaha, Suad Hasan, Syed Shahzad Conway, Barbara R. Aldeyab, Mamoon A. |
author_facet | Karasneh, Reema A. Khassawneh, Basheer Y. Al-Azzam, Sayer Al-Mistarehi, Abdel-Hameed Lattyak, William J. Aldiab, Motasem Kabbaha, Suad Hasan, Syed Shahzad Conway, Barbara R. Aldeyab, Mamoon A. |
author_sort | Karasneh, Reema A. |
collection | PubMed |
description | This study aimed to assess the risk factors for COVID-19 mortality among hospitalized patients in Jordan. All COVID-19 patients admitted to a tertiary hospital in Jordan from September 20, 2020, to August 8, 2021, were included in this study. Demographics, clinical characteristics, comorbidities, and laboratory results were extracted from the patients' electronic records. Multivariable logistic and machine learning (ML) methods were used to study variable importance. Out of 1,613 COVID-19 patients, 1,004 (62.2%) were discharged from the hospital (survived), while 609 (37.8%) died. Patients who were of elderly age (>65 years) (OR, 2.01; 95% CI, 1.28–3.16), current smokers (OR, 1.61; 95%CI, 1.17–2.23), and had severe or critical illness at admission ((OR, 1.56; 95%CI, 1.05–2.32) (OR, 2.94; 95%CI, 2.02–4.27); respectively), were at higher risk of mortality. Comorbidities including chronic kidney disease (OR, 2.90; 95% CI, 1.90–4.43), deep venous thrombosis (OR, 2.62; 95% CI, 1.08–6.35), malignancy (OR, 2.22; 95% CI, 1.46–3.38), diabetes (OR, 1.31; 95% CI, 1.04–1.65), and heart failure (OR, 1.51; 95% CI, 1.02–2.23) were significantly associated with increased risk of mortality. Laboratory abnormalities associated with mortality included hypernatremia (OR, 11.37; 95% CI, 4.33–29.81), elevated aspartate aminotransferase (OR, 1.81; 95% CI, 1.42–2.31), hypoalbuminemia (OR, 1.75; 95% CI, 1.37–2.25), and low platelets level (OR, 1.43; 95% CI, 1.05–1.95). Several demographic, clinical, and laboratory risk factors for COVID-19 mortality were identified. This study is the first to examine the risk factors associated with mortality using ML methods in the Middle East. This will contribute to a better understanding of the impact of the disease and improve the outcome of the pandemic worldwide. |
format | Online Article Text |
id | pubmed-9398873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-93988732022-09-06 Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East Karasneh, Reema A. Khassawneh, Basheer Y. Al-Azzam, Sayer Al-Mistarehi, Abdel-Hameed Lattyak, William J. Aldiab, Motasem Kabbaha, Suad Hasan, Syed Shahzad Conway, Barbara R. Aldeyab, Mamoon A. Int J Clin Pract Research Article This study aimed to assess the risk factors for COVID-19 mortality among hospitalized patients in Jordan. All COVID-19 patients admitted to a tertiary hospital in Jordan from September 20, 2020, to August 8, 2021, were included in this study. Demographics, clinical characteristics, comorbidities, and laboratory results were extracted from the patients' electronic records. Multivariable logistic and machine learning (ML) methods were used to study variable importance. Out of 1,613 COVID-19 patients, 1,004 (62.2%) were discharged from the hospital (survived), while 609 (37.8%) died. Patients who were of elderly age (>65 years) (OR, 2.01; 95% CI, 1.28–3.16), current smokers (OR, 1.61; 95%CI, 1.17–2.23), and had severe or critical illness at admission ((OR, 1.56; 95%CI, 1.05–2.32) (OR, 2.94; 95%CI, 2.02–4.27); respectively), were at higher risk of mortality. Comorbidities including chronic kidney disease (OR, 2.90; 95% CI, 1.90–4.43), deep venous thrombosis (OR, 2.62; 95% CI, 1.08–6.35), malignancy (OR, 2.22; 95% CI, 1.46–3.38), diabetes (OR, 1.31; 95% CI, 1.04–1.65), and heart failure (OR, 1.51; 95% CI, 1.02–2.23) were significantly associated with increased risk of mortality. Laboratory abnormalities associated with mortality included hypernatremia (OR, 11.37; 95% CI, 4.33–29.81), elevated aspartate aminotransferase (OR, 1.81; 95% CI, 1.42–2.31), hypoalbuminemia (OR, 1.75; 95% CI, 1.37–2.25), and low platelets level (OR, 1.43; 95% CI, 1.05–1.95). Several demographic, clinical, and laboratory risk factors for COVID-19 mortality were identified. This study is the first to examine the risk factors associated with mortality using ML methods in the Middle East. This will contribute to a better understanding of the impact of the disease and improve the outcome of the pandemic worldwide. Hindawi 2022-08-16 /pmc/articles/PMC9398873/ /pubmed/36072822 http://dx.doi.org/10.1155/2022/9617319 Text en Copyright © 2022 Reema A. Karasneh et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Karasneh, Reema A. Khassawneh, Basheer Y. Al-Azzam, Sayer Al-Mistarehi, Abdel-Hameed Lattyak, William J. Aldiab, Motasem Kabbaha, Suad Hasan, Syed Shahzad Conway, Barbara R. Aldeyab, Mamoon A. Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East |
title | Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East |
title_full | Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East |
title_fullStr | Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East |
title_full_unstemmed | Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East |
title_short | Risk Factors Associated with Mortality in COVID-19 Hospitalized Patients: Data from the Middle East |
title_sort | risk factors associated with mortality in covid-19 hospitalized patients: data from the middle east |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398873/ https://www.ncbi.nlm.nih.gov/pubmed/36072822 http://dx.doi.org/10.1155/2022/9617319 |
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