Fullerenes for the treatment of cancer: an emerging tool

Cancer is a most common cause of mortality globally. Available medicines possess severe side effects owing to their non-specific targeting. Hence, there is a need of an alternative in the healthcare system that should have high efficacy with the least side effects, also having the ability to achieve...

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Autores principales: Fernandes, Neha Benedicta, Shenoy, Raghavendra Udaya Kumar, Kajampady, Mandira Kashi, DCruz, Cleona E. M., Shirodkar, Rupesh K., Kumar, Lalit, Verma, Ruchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399030/
https://www.ncbi.nlm.nih.gov/pubmed/35790637
http://dx.doi.org/10.1007/s11356-022-21449-7
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author Fernandes, Neha Benedicta
Shenoy, Raghavendra Udaya Kumar
Kajampady, Mandira Kashi
DCruz, Cleona E. M.
Shirodkar, Rupesh K.
Kumar, Lalit
Verma, Ruchi
author_facet Fernandes, Neha Benedicta
Shenoy, Raghavendra Udaya Kumar
Kajampady, Mandira Kashi
DCruz, Cleona E. M.
Shirodkar, Rupesh K.
Kumar, Lalit
Verma, Ruchi
author_sort Fernandes, Neha Benedicta
collection PubMed
description Cancer is a most common cause of mortality globally. Available medicines possess severe side effects owing to their non-specific targeting. Hence, there is a need of an alternative in the healthcare system that should have high efficacy with the least side effects, also having the ability to achieve site-specific targeting and be reproducible. This is possible with the help of fullerenes. Fullerenes are having the unique physicochemical and photosensitizer properties. This article discusses the synthesis, functionalization, mechanism, various properties, and applications of C60 fullerenes in the treatment of cancer. The review article also addresses the various factors influencing the activity of fullerenes including the environmental conditions, toxicity profile, and future prospective. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-93990302022-08-25 Fullerenes for the treatment of cancer: an emerging tool Fernandes, Neha Benedicta Shenoy, Raghavendra Udaya Kumar Kajampady, Mandira Kashi DCruz, Cleona E. M. Shirodkar, Rupesh K. Kumar, Lalit Verma, Ruchi Environ Sci Pollut Res Int Review Article Cancer is a most common cause of mortality globally. Available medicines possess severe side effects owing to their non-specific targeting. Hence, there is a need of an alternative in the healthcare system that should have high efficacy with the least side effects, also having the ability to achieve site-specific targeting and be reproducible. This is possible with the help of fullerenes. Fullerenes are having the unique physicochemical and photosensitizer properties. This article discusses the synthesis, functionalization, mechanism, various properties, and applications of C60 fullerenes in the treatment of cancer. The review article also addresses the various factors influencing the activity of fullerenes including the environmental conditions, toxicity profile, and future prospective. GRAPHICAL ABSTRACT: [Image: see text] Springer Berlin Heidelberg 2022-07-06 2022 /pmc/articles/PMC9399030/ /pubmed/35790637 http://dx.doi.org/10.1007/s11356-022-21449-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Fernandes, Neha Benedicta
Shenoy, Raghavendra Udaya Kumar
Kajampady, Mandira Kashi
DCruz, Cleona E. M.
Shirodkar, Rupesh K.
Kumar, Lalit
Verma, Ruchi
Fullerenes for the treatment of cancer: an emerging tool
title Fullerenes for the treatment of cancer: an emerging tool
title_full Fullerenes for the treatment of cancer: an emerging tool
title_fullStr Fullerenes for the treatment of cancer: an emerging tool
title_full_unstemmed Fullerenes for the treatment of cancer: an emerging tool
title_short Fullerenes for the treatment of cancer: an emerging tool
title_sort fullerenes for the treatment of cancer: an emerging tool
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399030/
https://www.ncbi.nlm.nih.gov/pubmed/35790637
http://dx.doi.org/10.1007/s11356-022-21449-7
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