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Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis

Heart failure with preserved ejection fraction (HFpEF) has currently become a major concern in the aging society owing to its substantial and growing prevalence. Recent investigations regarding sacubitril/valsartan have suggested that there is a gender difference in the efficacy of the medication in...

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Autores principales: Sakai, Takahiro, Motoki, Hirohiko, Suzuki, Sho, Fuchida, Aya, Takeuchi, Takahiro, Otagiri, Kyuhachi, Kanai, Masafumi, Kimura, Kazuhiro, Minamisawa, Masatoshi, Yoshie, Koji, Saigusa, Tatsuya, Ebisawa, Soichiro, Okada, Ayako, Kitabayashi, Hiroshi, Kuwahara, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399051/
https://www.ncbi.nlm.nih.gov/pubmed/35461354
http://dx.doi.org/10.1007/s00380-022-02067-2
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author Sakai, Takahiro
Motoki, Hirohiko
Suzuki, Sho
Fuchida, Aya
Takeuchi, Takahiro
Otagiri, Kyuhachi
Kanai, Masafumi
Kimura, Kazuhiro
Minamisawa, Masatoshi
Yoshie, Koji
Saigusa, Tatsuya
Ebisawa, Soichiro
Okada, Ayako
Kitabayashi, Hiroshi
Kuwahara, Koichiro
author_facet Sakai, Takahiro
Motoki, Hirohiko
Suzuki, Sho
Fuchida, Aya
Takeuchi, Takahiro
Otagiri, Kyuhachi
Kanai, Masafumi
Kimura, Kazuhiro
Minamisawa, Masatoshi
Yoshie, Koji
Saigusa, Tatsuya
Ebisawa, Soichiro
Okada, Ayako
Kitabayashi, Hiroshi
Kuwahara, Koichiro
author_sort Sakai, Takahiro
collection PubMed
description Heart failure with preserved ejection fraction (HFpEF) has currently become a major concern in the aging society owing to its substantial and growing prevalence. Recent investigations regarding sacubitril/valsartan have suggested that there is a gender difference in the efficacy of the medication in HFpEF cohort. However, information of gender difference in clinical profiles, examination, and prognosis have not been well investigated. The present study aimed to evaluate the differences in baseline characteristics and outcomes between women and men in a Japanese HFpEF cohort. We analyzed the data from our prospective, observational, and multicenter cohort study. Overall, 1036 consecutive patients hospitalized for acute decompensated heart failure were enrolled. We defined patients with an ejection fraction (EF) of ≥ 50% as HFpEF. Patients with severe valvular disease were excluded; the remaining 379 patients (women: n = 201, men: n = 178) were assessed. Women were older than men [median: 85 (79–89) years vs. 83 (75–87) years, p = 0.013]. Diabetes mellitus, hyperuricemia, and coronary artery disease were more prevalent in men than in women (34.8% vs. 23.9%, p = 0.019, 23.6% vs. 11.4%, p = 0.002, and 23.0% vs. 11.9%, p = 0.005, respectively). EF was not significantly different between women and men. The cumulative incidence of cardiovascular death or hospitalization for congestive heart failure (CHF) was significantly lower in women than in men (log-rank p = 0.040). Women with HFpEF were older and less often exhibited an ischemic etiology; further, they were associated with a lower risk for cardiovascular death or hospitalization for CHF compared with men in the Japanese population.
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spelling pubmed-93990512022-08-25 Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis Sakai, Takahiro Motoki, Hirohiko Suzuki, Sho Fuchida, Aya Takeuchi, Takahiro Otagiri, Kyuhachi Kanai, Masafumi Kimura, Kazuhiro Minamisawa, Masatoshi Yoshie, Koji Saigusa, Tatsuya Ebisawa, Soichiro Okada, Ayako Kitabayashi, Hiroshi Kuwahara, Koichiro Heart Vessels Original Article Heart failure with preserved ejection fraction (HFpEF) has currently become a major concern in the aging society owing to its substantial and growing prevalence. Recent investigations regarding sacubitril/valsartan have suggested that there is a gender difference in the efficacy of the medication in HFpEF cohort. However, information of gender difference in clinical profiles, examination, and prognosis have not been well investigated. The present study aimed to evaluate the differences in baseline characteristics and outcomes between women and men in a Japanese HFpEF cohort. We analyzed the data from our prospective, observational, and multicenter cohort study. Overall, 1036 consecutive patients hospitalized for acute decompensated heart failure were enrolled. We defined patients with an ejection fraction (EF) of ≥ 50% as HFpEF. Patients with severe valvular disease were excluded; the remaining 379 patients (women: n = 201, men: n = 178) were assessed. Women were older than men [median: 85 (79–89) years vs. 83 (75–87) years, p = 0.013]. Diabetes mellitus, hyperuricemia, and coronary artery disease were more prevalent in men than in women (34.8% vs. 23.9%, p = 0.019, 23.6% vs. 11.4%, p = 0.002, and 23.0% vs. 11.9%, p = 0.005, respectively). EF was not significantly different between women and men. The cumulative incidence of cardiovascular death or hospitalization for congestive heart failure (CHF) was significantly lower in women than in men (log-rank p = 0.040). Women with HFpEF were older and less often exhibited an ischemic etiology; further, they were associated with a lower risk for cardiovascular death or hospitalization for CHF compared with men in the Japanese population. Springer Japan 2022-04-24 2022 /pmc/articles/PMC9399051/ /pubmed/35461354 http://dx.doi.org/10.1007/s00380-022-02067-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Sakai, Takahiro
Motoki, Hirohiko
Suzuki, Sho
Fuchida, Aya
Takeuchi, Takahiro
Otagiri, Kyuhachi
Kanai, Masafumi
Kimura, Kazuhiro
Minamisawa, Masatoshi
Yoshie, Koji
Saigusa, Tatsuya
Ebisawa, Soichiro
Okada, Ayako
Kitabayashi, Hiroshi
Kuwahara, Koichiro
Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis
title Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis
title_full Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis
title_fullStr Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis
title_full_unstemmed Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis
title_short Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis
title_sort gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399051/
https://www.ncbi.nlm.nih.gov/pubmed/35461354
http://dx.doi.org/10.1007/s00380-022-02067-2
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