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Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis

Treatment options for myocarditis are currently limited. Inhibition of calpains has been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries, but the underlying mechanism of action of calpains has not been elucidated. We investigated whether NOD-, LRR-, and pyrin domain-containing 3 (...

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Detalles Bibliográficos
Autores principales:	Liu, Xiaoxiao, Li, Minghui, Chen, Zhiwei, Yu, Yong, Shi, Hui, Yu, Ying, Wang, Yucheng, Chen, Ruizhen, Ge, Junbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399059/ https://www.ncbi.nlm.nih.gov/pubmed/35997820 http://dx.doi.org/10.1007/s00395-022-00948-1

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