ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is a widely utilized and successful strategy for breast cancer...

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Detalles Bibliográficos
Autores principales: Strillacci, Antonio, Sansone, Pasquale, Rajasekhar, Vinagolu K., Turkekul, Mesruh, Boyko, Vitaly, Meng, Fanli, Houck-Loomis, Brian, Brown, David, Berger, Michael F., Hendrickson, Ronald C., Chang, Qing, de Stanchina, Elisa, Pareja, Fresia, Reis-Filho, Jorge S., Rajappachetty, Ramya Segu, Del Priore, Isabella, Liu, Bo, Cai, Yanyan, Penson, Alex, Mastroleo, Chiara, Berishaj, Marjan, Borsetti, Francesca, Spisni, Enzo, Lyden, David, Chandarlapaty, Sarat, Bromberg, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399095/
https://www.ncbi.nlm.nih.gov/pubmed/35999225
http://dx.doi.org/10.1038/s41523-022-00470-6

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