KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress

Physiologic laminar shear stress (LSS) induces an endothelial gene expression profile that is vasculo-protective. In this report, we delineate how LSS mediates changes in the epigenetic landscape to promote this beneficial response. We show that under LSS, KLF4 interacts with the SWI/SNF nucleosome...

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Detalles Bibliográficos
Autores principales: Moonen, Jan-Renier, Chappell, James, Shi, Minyi, Shinohara, Tsutomu, Li, Dan, Mumbach, Maxwell R., Zhang, Fan, Nair, Ramesh V., Nasser, Joseph, Mai, Daniel H., Taylor, Shalina, Wang, Lingli, Metzger, Ross J., Chang, Howard Y., Engreitz, Jesse M., Snyder, Michael P., Rabinovitch, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399231/
https://www.ncbi.nlm.nih.gov/pubmed/35999210
http://dx.doi.org/10.1038/s41467-022-32566-9

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