Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery

PURPOSE: To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery. OBSERVATIONS: A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During...

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Detalles Bibliográficos
Autores principales: Price, Kenneth W., Pennesi, Mark E., Lauer, Andreas K., Bailey, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399261/
https://www.ncbi.nlm.nih.gov/pubmed/36034763
http://dx.doi.org/10.1016/j.ajoc.2022.101677
Descripción
Sumario:PURPOSE: To report a case of iatrogenic choroidal neovascularization (CNV) developing one month after subretinal gene therapy surgery. OBSERVATIONS: A 16-year-old male with biallelic RPE65 mutation associated retinal dystrophy was treated with subretinal voretigene neparvovec in the left eye. During initiation of a balanced salt solution pre-bleb, a faint and transient subretinal hemorrhage was observed at the retinotomy site. One month post-operatively, multi-modal imaging detected a CNV and a break in Bruch's membrane at the retinotomy site. The asymptomatic CNV was observed without treatment and resolved spontaneously. CONCLUSIONS & IMPORTANCE: As subretinal gene therapy surgery becomes more common, clinicians should monitor for possible trauma induced CNV associated with retinotomy formation and subretinal injection.

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