Dynamic regulation of P-TEFb by 7SK snRNP is integral to the DNA damage response to regulate chemotherapy sensitivity

Testicular germ cell tumors and closely related embryonal stem cells are exquisitely sensitive to cisplatin, a feature thought to be linked to their pluripotent state and p53 status. It remains unclear whether and how cellular state is coordinated with p53 to confer cisplatin sensitivity. Here, we r...

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Detalles Bibliográficos
Autores principales: Fang, Yin, Wang, Yan, Spector, Benjamin M., Xiao, Xue, Yang, Chao, Li, Ping, Yuan, Yuan, Ding, Ping, Xiao, Zhi-Xiong, Zhang, Peixuan, Qiu, Tong, Zhu, Xiaofeng, Price, David H., Li, Qintong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399290/
https://www.ncbi.nlm.nih.gov/pubmed/36034227
http://dx.doi.org/10.1016/j.isci.2022.104844

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