Cargando…
The emerging roles and mechanism of m6a in breast cancer progression
Breast cancer (BC) has continued to be the leading cause of cancer deaths in women, accompanied by highly molecular heterogeneity. N6-methyladenosine (m6A), a methylation that happens on adenosine N6, is the most abundant internal mRNA modification type in eukaryotic cells. Functionally, m6A methyla...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399344/ https://www.ncbi.nlm.nih.gov/pubmed/36035182 http://dx.doi.org/10.3389/fgene.2022.983564 |
_version_ | 1784772498333630464 |
---|---|
author | Zhou, Mengying Dong, Menglu Yang, Xue Gong, Jun Liao, Xinghua Zhang, Qi Liu, Zeming |
author_facet | Zhou, Mengying Dong, Menglu Yang, Xue Gong, Jun Liao, Xinghua Zhang, Qi Liu, Zeming |
author_sort | Zhou, Mengying |
collection | PubMed |
description | Breast cancer (BC) has continued to be the leading cause of cancer deaths in women, accompanied by highly molecular heterogeneity. N6-methyladenosine (m6A), a methylation that happens on adenosine N6, is the most abundant internal mRNA modification type in eukaryotic cells. Functionally, m6A methylation is a reversible modification process and is regulated by 3 enzymes with different functions, namely “writer”, “reader”, and “eraser”. Abnormal m6A modifications trigger the expression, activation, or inhibition of key signaling molecules in critical signaling pathways and the regulatory factors acting on them in BC. These m6A-related enzymes can not only be used as markers for accurate diagnosis, prediction of prognosis, and risk model construction, but also as effective targets for BC treatment. Here, we have emphasized the roles of different types of m6A-related enzymes reported in BC proliferation, invasion, and metastasis, as well as immune regulation. The comprehensive and in-depth exploration of the molecular mechanisms related to m6A will benefit in finding effective potential targets and effective stratified management of BC. |
format | Online Article Text |
id | pubmed-9399344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93993442022-08-25 The emerging roles and mechanism of m6a in breast cancer progression Zhou, Mengying Dong, Menglu Yang, Xue Gong, Jun Liao, Xinghua Zhang, Qi Liu, Zeming Front Genet Genetics Breast cancer (BC) has continued to be the leading cause of cancer deaths in women, accompanied by highly molecular heterogeneity. N6-methyladenosine (m6A), a methylation that happens on adenosine N6, is the most abundant internal mRNA modification type in eukaryotic cells. Functionally, m6A methylation is a reversible modification process and is regulated by 3 enzymes with different functions, namely “writer”, “reader”, and “eraser”. Abnormal m6A modifications trigger the expression, activation, or inhibition of key signaling molecules in critical signaling pathways and the regulatory factors acting on them in BC. These m6A-related enzymes can not only be used as markers for accurate diagnosis, prediction of prognosis, and risk model construction, but also as effective targets for BC treatment. Here, we have emphasized the roles of different types of m6A-related enzymes reported in BC proliferation, invasion, and metastasis, as well as immune regulation. The comprehensive and in-depth exploration of the molecular mechanisms related to m6A will benefit in finding effective potential targets and effective stratified management of BC. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399344/ /pubmed/36035182 http://dx.doi.org/10.3389/fgene.2022.983564 Text en Copyright © 2022 Zhou, Dong, Yang, Gong, Liao, Zhang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Zhou, Mengying Dong, Menglu Yang, Xue Gong, Jun Liao, Xinghua Zhang, Qi Liu, Zeming The emerging roles and mechanism of m6a in breast cancer progression |
title | The emerging roles and mechanism of m6a in breast cancer progression |
title_full | The emerging roles and mechanism of m6a in breast cancer progression |
title_fullStr | The emerging roles and mechanism of m6a in breast cancer progression |
title_full_unstemmed | The emerging roles and mechanism of m6a in breast cancer progression |
title_short | The emerging roles and mechanism of m6a in breast cancer progression |
title_sort | emerging roles and mechanism of m6a in breast cancer progression |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399344/ https://www.ncbi.nlm.nih.gov/pubmed/36035182 http://dx.doi.org/10.3389/fgene.2022.983564 |
work_keys_str_mv | AT zhoumengying theemergingrolesandmechanismofm6ainbreastcancerprogression AT dongmenglu theemergingrolesandmechanismofm6ainbreastcancerprogression AT yangxue theemergingrolesandmechanismofm6ainbreastcancerprogression AT gongjun theemergingrolesandmechanismofm6ainbreastcancerprogression AT liaoxinghua theemergingrolesandmechanismofm6ainbreastcancerprogression AT zhangqi theemergingrolesandmechanismofm6ainbreastcancerprogression AT liuzeming theemergingrolesandmechanismofm6ainbreastcancerprogression AT zhoumengying emergingrolesandmechanismofm6ainbreastcancerprogression AT dongmenglu emergingrolesandmechanismofm6ainbreastcancerprogression AT yangxue emergingrolesandmechanismofm6ainbreastcancerprogression AT gongjun emergingrolesandmechanismofm6ainbreastcancerprogression AT liaoxinghua emergingrolesandmechanismofm6ainbreastcancerprogression AT zhangqi emergingrolesandmechanismofm6ainbreastcancerprogression AT liuzeming emergingrolesandmechanismofm6ainbreastcancerprogression |