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Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis

Periprosthetic osteolysis is a major long-term complication of total joint replacement. A series of biological reactions caused by the interaction of wear particles at the prosthesis bone interface and surrounding bone tissue cells after artificial joint replacement are vital reasons for aseptic loo...

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Autores principales: Ma, Tian-Liang, Chen, Jing-Xian, Ke, Zhuo-Ran, Zhu, Peng, Hu, Yi-He, Xie, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399432/
https://www.ncbi.nlm.nih.gov/pubmed/36032702
http://dx.doi.org/10.3389/fbioe.2022.925841
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author Ma, Tian-Liang
Chen, Jing-Xian
Ke, Zhuo-Ran
Zhu, Peng
Hu, Yi-He
Xie, Jie
author_facet Ma, Tian-Liang
Chen, Jing-Xian
Ke, Zhuo-Ran
Zhu, Peng
Hu, Yi-He
Xie, Jie
author_sort Ma, Tian-Liang
collection PubMed
description Periprosthetic osteolysis is a major long-term complication of total joint replacement. A series of biological reactions caused by the interaction of wear particles at the prosthesis bone interface and surrounding bone tissue cells after artificial joint replacement are vital reasons for aseptic loosening. Disorder of bone metabolism and aseptic inflammation induced by wear particles are involved in the occurrence and development of aseptic loosening of the prosthesis. Promoting osteogenesis and angiogenesis and mediating osteoclasts and inflammation may be beneficial in preventing the aseptic loosening of the prosthesis. Current research about the prevention and treatment of aseptic loosening of the prosthesis focuses on drug, gene, and stem cell therapy and has not yet achieved satisfactory clinical efficacy or has not been used in clinical practice. Exosomes are a kind of typical extracellular vehicle. In recent years, stem cell exosomes (Exos) have been widely used to regulate bone metabolism, block inflammation, and have broad application prospects in tissue repair and cell therapy.
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spelling pubmed-93994322022-08-25 Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis Ma, Tian-Liang Chen, Jing-Xian Ke, Zhuo-Ran Zhu, Peng Hu, Yi-He Xie, Jie Front Bioeng Biotechnol Bioengineering and Biotechnology Periprosthetic osteolysis is a major long-term complication of total joint replacement. A series of biological reactions caused by the interaction of wear particles at the prosthesis bone interface and surrounding bone tissue cells after artificial joint replacement are vital reasons for aseptic loosening. Disorder of bone metabolism and aseptic inflammation induced by wear particles are involved in the occurrence and development of aseptic loosening of the prosthesis. Promoting osteogenesis and angiogenesis and mediating osteoclasts and inflammation may be beneficial in preventing the aseptic loosening of the prosthesis. Current research about the prevention and treatment of aseptic loosening of the prosthesis focuses on drug, gene, and stem cell therapy and has not yet achieved satisfactory clinical efficacy or has not been used in clinical practice. Exosomes are a kind of typical extracellular vehicle. In recent years, stem cell exosomes (Exos) have been widely used to regulate bone metabolism, block inflammation, and have broad application prospects in tissue repair and cell therapy. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399432/ /pubmed/36032702 http://dx.doi.org/10.3389/fbioe.2022.925841 Text en Copyright © 2022 Ma, Chen, Ke, Zhu, Hu and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Ma, Tian-Liang
Chen, Jing-Xian
Ke, Zhuo-Ran
Zhu, Peng
Hu, Yi-He
Xie, Jie
Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis
title Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis
title_full Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis
title_fullStr Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis
title_full_unstemmed Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis
title_short Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis
title_sort targeting regulation of stem cell exosomes: exploring novel strategies for aseptic loosening of joint prosthesis
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399432/
https://www.ncbi.nlm.nih.gov/pubmed/36032702
http://dx.doi.org/10.3389/fbioe.2022.925841
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