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Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

Cutaneous malignancies, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are common human tumors. The incidence of cutaneous malignancies is increasing worldwide, and the leading cause of death is malignant invasion and metastasis. The molecular biology of o...

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Detalles Bibliográficos
Autores principales: Liu, Fei, Li, Shenglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399465/
https://www.ncbi.nlm.nih.gov/pubmed/36034860
http://dx.doi.org/10.3389/fphar.2022.934396
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author Liu, Fei
Li, Shenglong
author_facet Liu, Fei
Li, Shenglong
author_sort Liu, Fei
collection PubMed
description Cutaneous malignancies, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are common human tumors. The incidence of cutaneous malignancies is increasing worldwide, and the leading cause of death is malignant invasion and metastasis. The molecular biology of oncogenes has drawn researchers’ attention because of the potential for targeted therapies. Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, have been studied extensively in recent years. This review summarizes the aspects of noncoding RNAs related to the metastasis mechanism of skin malignancies. Continuous research may facilitate the identification of new therapeutic targets and help elucidate the mechanism of tumor metastasis, thus providing new opportunities to improve the survival rate of patients with skin malignancies.
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spelling pubmed-93994652022-08-25 Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms Liu, Fei Li, Shenglong Front Pharmacol Pharmacology Cutaneous malignancies, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are common human tumors. The incidence of cutaneous malignancies is increasing worldwide, and the leading cause of death is malignant invasion and metastasis. The molecular biology of oncogenes has drawn researchers’ attention because of the potential for targeted therapies. Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, have been studied extensively in recent years. This review summarizes the aspects of noncoding RNAs related to the metastasis mechanism of skin malignancies. Continuous research may facilitate the identification of new therapeutic targets and help elucidate the mechanism of tumor metastasis, thus providing new opportunities to improve the survival rate of patients with skin malignancies. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399465/ /pubmed/36034860 http://dx.doi.org/10.3389/fphar.2022.934396 Text en Copyright © 2022 Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Fei
Li, Shenglong
Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms
title Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms
title_full Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms
title_fullStr Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms
title_full_unstemmed Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms
title_short Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms
title_sort non-coding rnas in skin cancers:biological roles and molecular mechanisms
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399465/
https://www.ncbi.nlm.nih.gov/pubmed/36034860
http://dx.doi.org/10.3389/fphar.2022.934396
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