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Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis

Proximal tubular epithelial cells respond to transforming growth factor β (TGFβ) to synthesize collagen I (α2) during renal fibrosis. The oncoprotein DJ-1 has previously been shown to promote tumorigenesis and prevent apoptosis of dopaminergic neurons; however, its role in fibrosis signaling is uncl...

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Detalles Bibliográficos
Autores principales:	Das, Falguni, Ghosh-Choudhury, Nandini, Maity, Soumya, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399488/ https://www.ncbi.nlm.nih.gov/pubmed/35835217 http://dx.doi.org/10.1016/j.jbc.2022.102246

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