Cargando…

EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review

Glutamate is the main excitatory neurotransmitter in the human central nervous system, responsible for a wide variety of normal physiological processes. Glutamatergic metabolism and its sequestration are tightly regulated in the normal human brain, and it has been demonstrated that dysregulation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wood, Oliver W. G., Yeung, Jason H. Y., Faull, Richard L. M., Kwakowsky, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399514/ https://www.ncbi.nlm.nih.gov/pubmed/36033606 http://dx.doi.org/10.3389/fnins.2022.952096

Ejemplares similares

Is EAAT2 a potential therapeutic intervention target for Alzheimer’s disease?
por: Wood, Oliver WG, et al.
Publicado: (2023)

EAAT2 Expression in the Hippocampus, Subiculum, Entorhinal Cortex and Superior Temporal Gyrus in Alzheimer’s Disease
por: Yeung, Jason H. Y., et al.
Publicado: (2021)

Vascular dysfunction in Alzheimer’s disease: a biomarker of disease progression and a potential therapeutic target
por: Govindpani, Karan, et al.
Publicado: (2019)

Is Hormone Replacement Therapy a Risk Factor or a Therapeutic Option for Alzheimer’s Disease?
por: Mills, Zoe B., et al.
Publicado: (2023)

iGluR expression in the hippocampal formation, entorhinal cortex, and superior temporal gyrus in Alzheimer’s disease
por: Yeung, Jason HY, et al.
Publicado: (2022)

Therapeutic potential of alpha 5 subunit containing GABA(A) receptors in Alzheimer’s disease
por: Kwakowsky, Andrea, et al.
Publicado: (2021)

The Acute Effects of Amyloid-Beta(1–42) on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus
por: Yeung, Jason H. Y., et al.
Publicado: (2020)

Cellular Physiology and Pathophysiology of EAAT Anion Channels
por: Kovermann, Peter, et al.
Publicado: (2022)

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
por: Lam, Patricia, et al.
Publicado: (2023)

Cellular and Synaptic Localization of EAAT2a in Human Cerebral Cortex
por: Melone, Marcello, et al.
Publicado: (2011)

Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex
por: Yeung, Jason H. Y., et al.
Publicado: (2021)

The Role of Microglia and Astrocytes in Huntington’s Disease
por: Palpagama, Thulani H., et al.
Publicado: (2019)

Neuroprotective Effect of Caffeine in Alzheimer’s Disease
por: M Yelanchezian, Y Mukish, et al.
Publicado: (2022)

Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer’s disease pathogenesis
por: Yeung, Jason HY, et al.
Publicado: (2023)

EAAT5 Glutamate Transporter-Mediated Inhibition in the Vertebrate Retina
por: Lukasiewcz, Peter D., et al.
Publicado: (2021)

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
por: Takahashi, Kou, et al.
Publicado: (2015)

Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer’s Disease
por: Kwakowsky, Andrea, et al.
Publicado: (2016)

Altered Grooming Syntax and Amphetamine-Induced Dopamine Release in EAAT3 Overexpressing Mice
por: Escobar, Angélica P., et al.
Publicado: (2021)

Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington’s disease
por: Bhatnagar, Akanksha, et al.
Publicado: (2023)

Klotho Sensitivity of the Neuronal Excitatory Amino Acid Transporters EAAT3 and EAAT4
por: Almilaji, Ahmad, et al.
Publicado: (2013)

Impaired Expression of GABA Signaling Components in the Alzheimer’s Disease Middle Temporal Gyrus
por: Govindpani, Karan, et al.
Publicado: (2020)

Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease
por: Govindpani, Karan, et al.
Publicado: (2017)

Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway
por: Kwakowsky, Andrea, et al.
Publicado: (2018)

A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics
por: Flanagan, Bronac, et al.
Publicado: (2021)

Glutamate Transporters EAAT4 and EAAT5 Are Expressed in Vestibular Hair Cells and Calyx Endings
por: Dalet, Antoine, et al.
Publicado: (2012)

mGluR1α expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer’s disease
por: Yeung, J.H.Y., et al.
Publicado: (2022)

Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders
por: Parkin, Georgia M, et al.
Publicado: (2018)

Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?
por: Govindpani, Karan, et al.
Publicado: (2019)

The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression
por: Kwakowsky, Andrea, et al.
Publicado: (2020)

Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals
por: Tang, Fu-Sheng, et al.
Publicado: (2022)

Pyroptosis as a candidate therapeutic target for Alzheimer’s disease
por: Huang, Yuehua, et al.
Publicado: (2022)

Current and Possible Future Therapeutic Options for Huntington’s Disease
por: Ferguson, Mackenzie W., et al.
Publicado: (2022)

The Contribution and Therapeutic Potential of Epigenetic Modifications in Alzheimer’s Disease
por: Wood, Ian C.
Publicado: (2018)

The Interplay Between Beta-Amyloid 1–42 (Aβ(1–42))-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits
por: Calvo-Flores Guzmán, Beatriz, et al.
Publicado: (2020)

Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis—a Systematic Review and Meta-Analysis of Preclinical Research
por: Elliott, Elizabeth, et al.
Publicado: (2020)

The Glutamate Transporter Subtypes EAAT4 and EAATs 1-3 Transport Glutamate with Dramatically Different Kinetics and Voltage Dependence but Share a Common Uptake Mechanism
por: Mim, Carsten, et al.
Publicado: (2005)

The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
por: Cellai, Lucrezia, et al.
Publicado: (2018)

Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer’s Disease
por: Ortí-Casañ, Natalia, et al.
Publicado: (2019)

Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review
por: Benedict, Christian, et al.
Publicado: (2018)

Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention
por: Zhang, Guimei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sg41646e6rqc7e6sor3h23b7hg