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Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection...

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Autores principales: Wang, Wenjing, Guan, Renzheng, Liu, Ziran, Zhang, Feng, Sun, Rui, Liu, Sitong, Shi, Xiaoyan, Su, Zhilei, Liang, Rongxiang, Hao, Kangyu, Wang, Zhaoguo, Liu, Xianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399728/
https://www.ncbi.nlm.nih.gov/pubmed/36033842
http://dx.doi.org/10.3389/fmicb.2022.935688
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author Wang, Wenjing
Guan, Renzheng
Liu, Ziran
Zhang, Feng
Sun, Rui
Liu, Sitong
Shi, Xiaoyan
Su, Zhilei
Liang, Rongxiang
Hao, Kangyu
Wang, Zhaoguo
Liu, Xianming
author_facet Wang, Wenjing
Guan, Renzheng
Liu, Ziran
Zhang, Feng
Sun, Rui
Liu, Sitong
Shi, Xiaoyan
Su, Zhilei
Liang, Rongxiang
Hao, Kangyu
Wang, Zhaoguo
Liu, Xianming
author_sort Wang, Wenjing
collection PubMed
description Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection methods and sampling criteria, determining the viral and bacterial etiology of HBoV infection using multiplex real-time PCR is yet to be reported. Herein, we aimed to further explore the pathogenicity of HBoV in patients with ARI by screening the viral and bacterial infections in children with ARI in Qingdao and comparing the epidemiological, clinical characteristics, and etiological results. Human bocavirus was identified in 28.1% of the samples, and further sequencing analysis of the detected HBoV confirmed 96.4% as HBoV1. The rate of HBoV as a single viral infection was 75%, and the rate of coinfection with bacteria was 66.1%, suggesting the need for continued monitoring of HBoV in children with ARIs. Clinical characterization suggested that HBoV infection may affect the function of organs, such as the liver, kidney, and heart, and the blood acid–base balance. Additionally, it is essential to promote awareness about the importance of disinfection and sterilization of the hospital environment and standardizing operations. The interactions between HBoV and other pathogens remain to be investigated in further detail in the future.
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spelling pubmed-93997282022-08-25 Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China Wang, Wenjing Guan, Renzheng Liu, Ziran Zhang, Feng Sun, Rui Liu, Sitong Shi, Xiaoyan Su, Zhilei Liang, Rongxiang Hao, Kangyu Wang, Zhaoguo Liu, Xianming Front Microbiol Microbiology Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection methods and sampling criteria, determining the viral and bacterial etiology of HBoV infection using multiplex real-time PCR is yet to be reported. Herein, we aimed to further explore the pathogenicity of HBoV in patients with ARI by screening the viral and bacterial infections in children with ARI in Qingdao and comparing the epidemiological, clinical characteristics, and etiological results. Human bocavirus was identified in 28.1% of the samples, and further sequencing analysis of the detected HBoV confirmed 96.4% as HBoV1. The rate of HBoV as a single viral infection was 75%, and the rate of coinfection with bacteria was 66.1%, suggesting the need for continued monitoring of HBoV in children with ARIs. Clinical characterization suggested that HBoV infection may affect the function of organs, such as the liver, kidney, and heart, and the blood acid–base balance. Additionally, it is essential to promote awareness about the importance of disinfection and sterilization of the hospital environment and standardizing operations. The interactions between HBoV and other pathogens remain to be investigated in further detail in the future. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399728/ /pubmed/36033842 http://dx.doi.org/10.3389/fmicb.2022.935688 Text en Copyright © 2022 Wang, Guan, Liu, Zhang, Sun, Liu, Shi, Su, Liang, Hao, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Wenjing
Guan, Renzheng
Liu, Ziran
Zhang, Feng
Sun, Rui
Liu, Sitong
Shi, Xiaoyan
Su, Zhilei
Liang, Rongxiang
Hao, Kangyu
Wang, Zhaoguo
Liu, Xianming
Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China
title Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China
title_full Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China
title_fullStr Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China
title_full_unstemmed Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China
title_short Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China
title_sort epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in qingdao, china
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399728/
https://www.ncbi.nlm.nih.gov/pubmed/36033842
http://dx.doi.org/10.3389/fmicb.2022.935688
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