Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) develops rapidly and has high mortality. ALI/ARDS is mainly manifested as acute or progressive hypoxic respiratory failure. At present, there is no effective clinical intervention for the treatment of ALI/ARDS. Mesenchymal stromal ce...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Xiao, Kun, Xie, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399751/
https://www.ncbi.nlm.nih.gov/pubmed/36036014
http://dx.doi.org/10.3389/fcell.2022.951764
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author Liu, Chang
Xiao, Kun
Xie, Lixin
author_facet Liu, Chang
Xiao, Kun
Xie, Lixin
author_sort Liu, Chang
collection PubMed
description Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) develops rapidly and has high mortality. ALI/ARDS is mainly manifested as acute or progressive hypoxic respiratory failure. At present, there is no effective clinical intervention for the treatment of ALI/ARDS. Mesenchymal stromal cells (MSCs) show promise for ALI/ARDS treatment due to their biological characteristics, easy cultivation, low immunogenicity, and abundant sources. The therapeutic mechanisms of MSCs in diseases are related to their homing capability, multidirectional differentiation, anti-inflammatory effect, paracrine signaling, macrophage polarization, the polarization of the MSCs themselves, and MSCs-derived exosomes. In this review, we discuss the pathogenesis of ALI/ARDS along with the biological characteristics and mechanisms of MSCs in the treatment of ALI/ARDS.
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spelling pubmed-93997512022-08-25 Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome Liu, Chang Xiao, Kun Xie, Lixin Front Cell Dev Biol Cell and Developmental Biology Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) develops rapidly and has high mortality. ALI/ARDS is mainly manifested as acute or progressive hypoxic respiratory failure. At present, there is no effective clinical intervention for the treatment of ALI/ARDS. Mesenchymal stromal cells (MSCs) show promise for ALI/ARDS treatment due to their biological characteristics, easy cultivation, low immunogenicity, and abundant sources. The therapeutic mechanisms of MSCs in diseases are related to their homing capability, multidirectional differentiation, anti-inflammatory effect, paracrine signaling, macrophage polarization, the polarization of the MSCs themselves, and MSCs-derived exosomes. In this review, we discuss the pathogenesis of ALI/ARDS along with the biological characteristics and mechanisms of MSCs in the treatment of ALI/ARDS. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399751/ /pubmed/36036014 http://dx.doi.org/10.3389/fcell.2022.951764 Text en Copyright © 2022 Liu, Xiao and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Chang
Xiao, Kun
Xie, Lixin
Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
title Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
title_full Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
title_fullStr Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
title_full_unstemmed Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
title_short Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
title_sort advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399751/
https://www.ncbi.nlm.nih.gov/pubmed/36036014
http://dx.doi.org/10.3389/fcell.2022.951764
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AT xielixin advancesinmesenchymalstromalcelltherapyforacutelunginjuryacuterespiratorydistresssyndrome

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