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The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity

Immune checkpoint inhibitors, medications that boost host immune response to tumor cells, are now at the forefront of anti-cancer therapy. While efficacious in the treatment of patients with advanced cancer, immune checkpoint inhibitors can lead to serious autoimmune side effects involving any organ...

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Autores principales: Moss, Emily M., Perazella, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399765/
https://www.ncbi.nlm.nih.gov/pubmed/36035427
http://dx.doi.org/10.3389/fmed.2022.964335
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author Moss, Emily M.
Perazella, Mark A.
author_facet Moss, Emily M.
Perazella, Mark A.
author_sort Moss, Emily M.
collection PubMed
description Immune checkpoint inhibitors, medications that boost host immune response to tumor cells, are now at the forefront of anti-cancer therapy. While efficacious in the treatment of patients with advanced cancer, immune checkpoint inhibitors can lead to serious autoimmune side effects involving any organ in the body. Immune checkpoint inhibitor nephrotoxicity is an increasingly recognized cause of acute kidney injury in patients with cancer. This review discusses the clinical and histopathologic diagnosis of immune checkpoint inhibitor nephrotoxicity, highlighting the need for more reliable non-invasive diagnostic testing. We focus on the controversy surrounding the role of kidney biopsy in diagnosis and management of suspected immune checkpoint inhibitor toxicity with inclination toward pursuing kidney biopsy in certain outlined circumstances. Finally, we briefly discuss treatment of immune checkpoint inhibitor nephrotoxicity and the decision to re-challenge immunotherapy in patients who experience these adverse events.
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spelling pubmed-93997652022-08-25 The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity Moss, Emily M. Perazella, Mark A. Front Med (Lausanne) Medicine Immune checkpoint inhibitors, medications that boost host immune response to tumor cells, are now at the forefront of anti-cancer therapy. While efficacious in the treatment of patients with advanced cancer, immune checkpoint inhibitors can lead to serious autoimmune side effects involving any organ in the body. Immune checkpoint inhibitor nephrotoxicity is an increasingly recognized cause of acute kidney injury in patients with cancer. This review discusses the clinical and histopathologic diagnosis of immune checkpoint inhibitor nephrotoxicity, highlighting the need for more reliable non-invasive diagnostic testing. We focus on the controversy surrounding the role of kidney biopsy in diagnosis and management of suspected immune checkpoint inhibitor toxicity with inclination toward pursuing kidney biopsy in certain outlined circumstances. Finally, we briefly discuss treatment of immune checkpoint inhibitor nephrotoxicity and the decision to re-challenge immunotherapy in patients who experience these adverse events. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399765/ /pubmed/36035427 http://dx.doi.org/10.3389/fmed.2022.964335 Text en Copyright © 2022 Moss and Perazella. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Moss, Emily M.
Perazella, Mark A.
The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
title The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
title_full The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
title_fullStr The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
title_full_unstemmed The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
title_short The role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
title_sort role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399765/
https://www.ncbi.nlm.nih.gov/pubmed/36035427
http://dx.doi.org/10.3389/fmed.2022.964335
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