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A system of real-time neural recording and stimulation and its potential application in blood pressure modulation

Hypertension is one of the most prevalent chronic diseases that affects more than 20% of the adult population worldwide, but fortunately, most of their blood pressure can be effectively controlled via drug treatment. However, there still remains 5–30% of patients clinically who do not respond well t...

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Autores principales: Shen, Anruo, Li, Runhuan, Li, Yiran, Guo, Jinyao, Wang, Jiguang, Sui, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399767/
https://www.ncbi.nlm.nih.gov/pubmed/36035774
http://dx.doi.org/10.3389/fmedt.2022.941686
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author Shen, Anruo
Li, Runhuan
Li, Yiran
Guo, Jinyao
Wang, Jiguang
Sui, Xiaohong
author_facet Shen, Anruo
Li, Runhuan
Li, Yiran
Guo, Jinyao
Wang, Jiguang
Sui, Xiaohong
author_sort Shen, Anruo
collection PubMed
description Hypertension is one of the most prevalent chronic diseases that affects more than 20% of the adult population worldwide, but fortunately, most of their blood pressure can be effectively controlled via drug treatment. However, there still remains 5–30% of patients clinically who do not respond well to conventional medication, while the non-drug treatments currently existing are struggling with major drawbacks like irreversible nerve damage, huge side effects, and even non-effectiveness. In this study, based on the physiological regulation mechanism of blood pressure and state-of-the-art neuromodulation technique, we worked along with the vagus nerve stimulation scheme, developed, and explored whether and how a real-time neural recording and stimulation system could provide an insight into self-adaptive modulation in the blood pressure, in the hope to crack a crevice in the closed-loop treatment for resistant hypertension. Unlike traditional neuromodulation devices, additional signal recording and real-time wireless transmission functions are added to the same device to realize the features of a dynamic monitor and modulator. The system is tested both in vitro and in vivo, showing decent electrical performance of 8 kHz sampling rate and flexible stimulation outputs which sufficiently covers our needs in manipulating neural activities of interest. A relatively stable drop in the blood pressure resulting from stimulation was observed and specific patterns in the vagus nerve signals relating to blood pressure could also be primarily identified. This laid a solid foundation for further studies on the final realization of closed-loop automatic adjustment for resistive hypertension treatment.
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spelling pubmed-93997672022-08-25 A system of real-time neural recording and stimulation and its potential application in blood pressure modulation Shen, Anruo Li, Runhuan Li, Yiran Guo, Jinyao Wang, Jiguang Sui, Xiaohong Front Med Technol Medical Technology Hypertension is one of the most prevalent chronic diseases that affects more than 20% of the adult population worldwide, but fortunately, most of their blood pressure can be effectively controlled via drug treatment. However, there still remains 5–30% of patients clinically who do not respond well to conventional medication, while the non-drug treatments currently existing are struggling with major drawbacks like irreversible nerve damage, huge side effects, and even non-effectiveness. In this study, based on the physiological regulation mechanism of blood pressure and state-of-the-art neuromodulation technique, we worked along with the vagus nerve stimulation scheme, developed, and explored whether and how a real-time neural recording and stimulation system could provide an insight into self-adaptive modulation in the blood pressure, in the hope to crack a crevice in the closed-loop treatment for resistant hypertension. Unlike traditional neuromodulation devices, additional signal recording and real-time wireless transmission functions are added to the same device to realize the features of a dynamic monitor and modulator. The system is tested both in vitro and in vivo, showing decent electrical performance of 8 kHz sampling rate and flexible stimulation outputs which sufficiently covers our needs in manipulating neural activities of interest. A relatively stable drop in the blood pressure resulting from stimulation was observed and specific patterns in the vagus nerve signals relating to blood pressure could also be primarily identified. This laid a solid foundation for further studies on the final realization of closed-loop automatic adjustment for resistive hypertension treatment. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399767/ /pubmed/36035774 http://dx.doi.org/10.3389/fmedt.2022.941686 Text en Copyright © 2022 Shen, Li, Li, Guo, Wang and Sui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medical Technology
Shen, Anruo
Li, Runhuan
Li, Yiran
Guo, Jinyao
Wang, Jiguang
Sui, Xiaohong
A system of real-time neural recording and stimulation and its potential application in blood pressure modulation
title A system of real-time neural recording and stimulation and its potential application in blood pressure modulation
title_full A system of real-time neural recording and stimulation and its potential application in blood pressure modulation
title_fullStr A system of real-time neural recording and stimulation and its potential application in blood pressure modulation
title_full_unstemmed A system of real-time neural recording and stimulation and its potential application in blood pressure modulation
title_short A system of real-time neural recording and stimulation and its potential application in blood pressure modulation
title_sort system of real-time neural recording and stimulation and its potential application in blood pressure modulation
topic Medical Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399767/
https://www.ncbi.nlm.nih.gov/pubmed/36035774
http://dx.doi.org/10.3389/fmedt.2022.941686
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