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Roles of microglial mitophagy in neurological disorders
Microglia are the resident innate immune cells in the central nervous system (CNS) that serve as the first line innate immunity in response to pathogen invasion, ischemia and other pathological stimuli. Once activated, they rapidly release a variety of inflammatory cytokines and phagocytose pathogen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399802/ https://www.ncbi.nlm.nih.gov/pubmed/36034136 http://dx.doi.org/10.3389/fnagi.2022.979869 |
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author | Liu, Yang Wang, Miao Hou, Xiao-Ou Hu, Li-Fang |
author_facet | Liu, Yang Wang, Miao Hou, Xiao-Ou Hu, Li-Fang |
author_sort | Liu, Yang |
collection | PubMed |
description | Microglia are the resident innate immune cells in the central nervous system (CNS) that serve as the first line innate immunity in response to pathogen invasion, ischemia and other pathological stimuli. Once activated, they rapidly release a variety of inflammatory cytokines and phagocytose pathogens or cell debris (termed neuroinflammation), which is beneficial for maintaining brain homeostasis if appropriately activated. However, excessive or uncontrolled neuroinflammation may damage neurons and exacerbate the pathologies in neurological disorders. Microglia are highly dynamic cells, dependent on energy supply from mitochondria. Moreover, dysfunctional mitochondria can serve as a signaling platform to facilitate innate immune responses in microglia. Mitophagy is a means of clearing damaged or redundant mitochondria, playing a critical role in the quality control of mitochondrial homeostasis and turnover. Mounting evidence has shown that mitophagy not only limits the inflammatory response in microglia but also affects their phagocytosis, whereas mitochondria dysfunction and mitophagy defects are associated with aging and neurological disorders. Therefore, targeting microglial mitophagy is a promising therapeutic strategy for neurological disorders. This article reviews and highlights the role and regulation of mitophagy in microglia in neurological conditions, and the research progress in manipulating microglial mitophagy and future directions in this field are also discussed. |
format | Online Article Text |
id | pubmed-9399802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93998022022-08-25 Roles of microglial mitophagy in neurological disorders Liu, Yang Wang, Miao Hou, Xiao-Ou Hu, Li-Fang Front Aging Neurosci Aging Neuroscience Microglia are the resident innate immune cells in the central nervous system (CNS) that serve as the first line innate immunity in response to pathogen invasion, ischemia and other pathological stimuli. Once activated, they rapidly release a variety of inflammatory cytokines and phagocytose pathogens or cell debris (termed neuroinflammation), which is beneficial for maintaining brain homeostasis if appropriately activated. However, excessive or uncontrolled neuroinflammation may damage neurons and exacerbate the pathologies in neurological disorders. Microglia are highly dynamic cells, dependent on energy supply from mitochondria. Moreover, dysfunctional mitochondria can serve as a signaling platform to facilitate innate immune responses in microglia. Mitophagy is a means of clearing damaged or redundant mitochondria, playing a critical role in the quality control of mitochondrial homeostasis and turnover. Mounting evidence has shown that mitophagy not only limits the inflammatory response in microglia but also affects their phagocytosis, whereas mitochondria dysfunction and mitophagy defects are associated with aging and neurological disorders. Therefore, targeting microglial mitophagy is a promising therapeutic strategy for neurological disorders. This article reviews and highlights the role and regulation of mitophagy in microglia in neurological conditions, and the research progress in manipulating microglial mitophagy and future directions in this field are also discussed. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399802/ /pubmed/36034136 http://dx.doi.org/10.3389/fnagi.2022.979869 Text en Copyright © 2022 Liu, Wang, Hou and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Liu, Yang Wang, Miao Hou, Xiao-Ou Hu, Li-Fang Roles of microglial mitophagy in neurological disorders |
title | Roles of microglial mitophagy in neurological disorders |
title_full | Roles of microglial mitophagy in neurological disorders |
title_fullStr | Roles of microglial mitophagy in neurological disorders |
title_full_unstemmed | Roles of microglial mitophagy in neurological disorders |
title_short | Roles of microglial mitophagy in neurological disorders |
title_sort | roles of microglial mitophagy in neurological disorders |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399802/ https://www.ncbi.nlm.nih.gov/pubmed/36034136 http://dx.doi.org/10.3389/fnagi.2022.979869 |
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