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Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

Background: Preeclampsia is a serious pregnancy complication that affects 5%–10% of the obstetric population. Objective: To study inflammatory markers associated with preeclampsia. Search Strategy: Searches of articles on the topic published over a 10-year period (2009–2019) were performed in three...

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Autores principales: Veiga, Eduardo Carvalho de Arruda, Korkes, Henri Augusto, Salomão, Karina Bezerra, Cavalli, Ricardo Carvalho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399808/
https://www.ncbi.nlm.nih.gov/pubmed/36034841
http://dx.doi.org/10.3389/fphar.2022.966400
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author Veiga, Eduardo Carvalho de Arruda
Korkes, Henri Augusto
Salomão, Karina Bezerra
Cavalli, Ricardo Carvalho
author_facet Veiga, Eduardo Carvalho de Arruda
Korkes, Henri Augusto
Salomão, Karina Bezerra
Cavalli, Ricardo Carvalho
author_sort Veiga, Eduardo Carvalho de Arruda
collection PubMed
description Background: Preeclampsia is a serious pregnancy complication that affects 5%–10% of the obstetric population. Objective: To study inflammatory markers associated with preeclampsia. Search Strategy: Searches of articles on the topic published over a 10-year period (2009–2019) were performed in three databases (PubMed, Cochrane, and Embase) using the keywords preeclampsia and inflammatory markers. The PubMed search using 10 years and humans as filters retrieved 124 articles. Using an advanced search strategy, 0 articles were identified in Embase and 10 articles in Cochrane. After screening and eligibility assessment, 13 articles were included in the systematic review and meta-analysis. Meta-analysis and quality assessment of the studies were performed using the Review Manager 5.3 program. Results: For meta-analysis, women with preeclampsia were compared to control women, i.e., pregnancies without arterial hypertension. Leptin levels were significantly higher (p < 0.0002) in women with preeclampsia compared to controls. Total cholesterol was also significantly elevated in women with preeclampsia (p < 0.0001). There was no significant difference in HDL between groups, but women with preeclampsia had significantly increased LDL (p < 0.01). The same was observed for triglycerides, which were significantly increased in women with preeclampsia (p < 0.04) compared to controls. Analysis of TNF-alpha, an important inflammatory marker, showed higher levels in women with preeclampsia (p < 0.03) compared to controls. The same was observed for another important inflammatory marker, interleukin 6, which was significantly increased in women with preeclampsia (p < 0.0002). There was a significant increase of C-reactive protein in women with preeclampsia (p < 0.003) compared to controls. Conclusion: Women with preeclampsia have increased levels of inflammatory markers compared to control women.
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spelling pubmed-93998082022-08-25 Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review Veiga, Eduardo Carvalho de Arruda Korkes, Henri Augusto Salomão, Karina Bezerra Cavalli, Ricardo Carvalho Front Pharmacol Pharmacology Background: Preeclampsia is a serious pregnancy complication that affects 5%–10% of the obstetric population. Objective: To study inflammatory markers associated with preeclampsia. Search Strategy: Searches of articles on the topic published over a 10-year period (2009–2019) were performed in three databases (PubMed, Cochrane, and Embase) using the keywords preeclampsia and inflammatory markers. The PubMed search using 10 years and humans as filters retrieved 124 articles. Using an advanced search strategy, 0 articles were identified in Embase and 10 articles in Cochrane. After screening and eligibility assessment, 13 articles were included in the systematic review and meta-analysis. Meta-analysis and quality assessment of the studies were performed using the Review Manager 5.3 program. Results: For meta-analysis, women with preeclampsia were compared to control women, i.e., pregnancies without arterial hypertension. Leptin levels were significantly higher (p < 0.0002) in women with preeclampsia compared to controls. Total cholesterol was also significantly elevated in women with preeclampsia (p < 0.0001). There was no significant difference in HDL between groups, but women with preeclampsia had significantly increased LDL (p < 0.01). The same was observed for triglycerides, which were significantly increased in women with preeclampsia (p < 0.04) compared to controls. Analysis of TNF-alpha, an important inflammatory marker, showed higher levels in women with preeclampsia (p < 0.03) compared to controls. The same was observed for another important inflammatory marker, interleukin 6, which was significantly increased in women with preeclampsia (p < 0.0002). There was a significant increase of C-reactive protein in women with preeclampsia (p < 0.003) compared to controls. Conclusion: Women with preeclampsia have increased levels of inflammatory markers compared to control women. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399808/ /pubmed/36034841 http://dx.doi.org/10.3389/fphar.2022.966400 Text en Copyright © 2022 Veiga, Korkes, Salomão and Cavalli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Veiga, Eduardo Carvalho de Arruda
Korkes, Henri Augusto
Salomão, Karina Bezerra
Cavalli, Ricardo Carvalho
Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
title Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
title_full Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
title_fullStr Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
title_full_unstemmed Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
title_short Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
title_sort association of leptin and other inflammatory markers with preeclampsia: a systematic review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399808/
https://www.ncbi.nlm.nih.gov/pubmed/36034841
http://dx.doi.org/10.3389/fphar.2022.966400
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