Cargando…
Neuroendocrine regulation of female aggression
Classically the neurobiology of aggression has been studied exclusively in males. Thus, females have been considered mildly aggressive except during lactation. Interestingly, recent studies in rodents and humans have revealed that non-lactating females can show exacerbated and pathological aggressio...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399833/ https://www.ncbi.nlm.nih.gov/pubmed/36034455 http://dx.doi.org/10.3389/fendo.2022.957114 |
_version_ | 1784772616261730304 |
---|---|
author | Oliveira, Vinícius Elias de Moura Bakker, Julie |
author_facet | Oliveira, Vinícius Elias de Moura Bakker, Julie |
author_sort | Oliveira, Vinícius Elias de Moura |
collection | PubMed |
description | Classically the neurobiology of aggression has been studied exclusively in males. Thus, females have been considered mildly aggressive except during lactation. Interestingly, recent studies in rodents and humans have revealed that non-lactating females can show exacerbated and pathological aggression similarly to males. This review provides an overview of recent findings on the neuroendocrine mechanisms regulating aggressive behavior in females. In particular, the focus will be on novel rodent models of exaggerated aggression established in non-lactating females. Among the neuromodulatory systems influencing female aggression, special attention has been given to sex-steroids and sex-steroid-sensitive neuronal populations (i.e., the core nuclei of the neural pathway of aggression) as well as to the neuropeptides oxytocin and vasopressin which are major players in the regulation of social behaviors. |
format | Online Article Text |
id | pubmed-9399833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93998332022-08-25 Neuroendocrine regulation of female aggression Oliveira, Vinícius Elias de Moura Bakker, Julie Front Endocrinol (Lausanne) Endocrinology Classically the neurobiology of aggression has been studied exclusively in males. Thus, females have been considered mildly aggressive except during lactation. Interestingly, recent studies in rodents and humans have revealed that non-lactating females can show exacerbated and pathological aggression similarly to males. This review provides an overview of recent findings on the neuroendocrine mechanisms regulating aggressive behavior in females. In particular, the focus will be on novel rodent models of exaggerated aggression established in non-lactating females. Among the neuromodulatory systems influencing female aggression, special attention has been given to sex-steroids and sex-steroid-sensitive neuronal populations (i.e., the core nuclei of the neural pathway of aggression) as well as to the neuropeptides oxytocin and vasopressin which are major players in the regulation of social behaviors. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399833/ /pubmed/36034455 http://dx.doi.org/10.3389/fendo.2022.957114 Text en Copyright © 2022 Oliveira and Bakker https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Oliveira, Vinícius Elias de Moura Bakker, Julie Neuroendocrine regulation of female aggression |
title | Neuroendocrine regulation of female aggression |
title_full | Neuroendocrine regulation of female aggression |
title_fullStr | Neuroendocrine regulation of female aggression |
title_full_unstemmed | Neuroendocrine regulation of female aggression |
title_short | Neuroendocrine regulation of female aggression |
title_sort | neuroendocrine regulation of female aggression |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399833/ https://www.ncbi.nlm.nih.gov/pubmed/36034455 http://dx.doi.org/10.3389/fendo.2022.957114 |
work_keys_str_mv | AT oliveiraviniciuseliasdemoura neuroendocrineregulationoffemaleaggression AT bakkerjulie neuroendocrineregulationoffemaleaggression |