Insulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes

Insulin is considered to be a key antigenic target of T cells in Type 1 Diabetes (T1D) and autoimmune diabetes in the NOD mouse with particular focus on the B-chain amino acid sequence B:9-23 as the primary epitope. Our lab previously discovered that hybrid insulin peptides (HIPs), comprised of insu...

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Detalles Bibliográficos
Autores principales: Wenzlau, Janet M., DiLisio, James E., Barbour, Gene, Dang, Mylinh, Hohenstein, Anita C., Nakayama, Maki, Delong, Thomas, Baker, Rocky L., Haskins, Kathryn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399855/
https://www.ncbi.nlm.nih.gov/pubmed/36032090
http://dx.doi.org/10.3389/fimmu.2022.926650

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