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Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders

BACKGROUND AND RATIONALE: Autism spectrum disorder (ASD) is a neuropsychiatric disorder that has no curative treatment. Little is known about the brain laterality in patients with ASD. F-18 fluorodeoxyglucose positron emission computed tomography (F-18 FDG PET/CT) is a neuroimaging technique that is...

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Autores principales: Keeratitanont, Keattichai, Theerakulpisut, Daris, Auvichayapat, Narong, Suphakunpinyo, Chanyut, Patjanasoontorn, Niramol, Tiamkao, Somsak, Tepmongkol, Supatporn, Khiewvan, Benjapa, Raruenrom, Yutapong, Srisuruk, Piyawan, Paholpak, Suchat, Auvichayapat, Paradee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399910/
https://www.ncbi.nlm.nih.gov/pubmed/36034502
http://dx.doi.org/10.3389/fnmol.2022.901016
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author Keeratitanont, Keattichai
Theerakulpisut, Daris
Auvichayapat, Narong
Suphakunpinyo, Chanyut
Patjanasoontorn, Niramol
Tiamkao, Somsak
Tepmongkol, Supatporn
Khiewvan, Benjapa
Raruenrom, Yutapong
Srisuruk, Piyawan
Paholpak, Suchat
Auvichayapat, Paradee
author_facet Keeratitanont, Keattichai
Theerakulpisut, Daris
Auvichayapat, Narong
Suphakunpinyo, Chanyut
Patjanasoontorn, Niramol
Tiamkao, Somsak
Tepmongkol, Supatporn
Khiewvan, Benjapa
Raruenrom, Yutapong
Srisuruk, Piyawan
Paholpak, Suchat
Auvichayapat, Paradee
author_sort Keeratitanont, Keattichai
collection PubMed
description BACKGROUND AND RATIONALE: Autism spectrum disorder (ASD) is a neuropsychiatric disorder that has no curative treatment. Little is known about the brain laterality in patients with ASD. F-18 fluorodeoxyglucose positron emission computed tomography (F-18 FDG PET/CT) is a neuroimaging technique that is suitable for ASD owing to its ability to detect whole brain functional abnormalities in a short time and is feasible in ASD patients. The purpose of this study was to evaluate brain laterality using F-18 FDG PET/CT in patients with high-functioning ASD. MATERIALS AND METHODS: This case-control study recruited eight ASD patients who met the DSM-5 criteria, the recorded data of eight controls matched for age, sex, and handedness were also enrolled. The resting state of brain glucose metabolism in the regions of interest (ROIs) was analyzed using the Q.Brain software. Brain glucose metabolism and laterality index in each ROI of ASD patients were compared with those of the controls. The pattern of brain metabolism was analyzed using visual analysis and is reported in the data description. RESULTS: The ASD group’s overall brain glucose metabolism was lower than that of the control group in both the left and right hemispheres, with mean differences of 1.54 and 1.21, respectively. We found statistically lower mean glucose metabolism for ASD patients than controls in the left prefrontal lateral (Z = 1.96, p = 0.049). The left laterality index was found in nine ROIs for ASD and 11 ROIs for the control. The left laterality index in the ASD group was significantly lower than that in the control group in the prefrontal lateral (Z = 2.52, p = 0.012), precuneus (Z = 2.10, p = 0.036), and parietal inferior (Z = 1.96, p = 0.049) regions. CONCLUSION: Individuals with ASD have lower brain glucose metabolism than control. In addition, the number of ROIs for left laterality index in the ASD group was lower than control. Left laterality defects may be one of the causes of ASD. This knowledge can be useful in the treatment of ASD by increasing the left-brain metabolism. This trial was registered in the Thai Clinical Trials Registry (TCTR20210705005).
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spelling pubmed-93999102022-08-25 Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders Keeratitanont, Keattichai Theerakulpisut, Daris Auvichayapat, Narong Suphakunpinyo, Chanyut Patjanasoontorn, Niramol Tiamkao, Somsak Tepmongkol, Supatporn Khiewvan, Benjapa Raruenrom, Yutapong Srisuruk, Piyawan Paholpak, Suchat Auvichayapat, Paradee Front Mol Neurosci Neuroscience BACKGROUND AND RATIONALE: Autism spectrum disorder (ASD) is a neuropsychiatric disorder that has no curative treatment. Little is known about the brain laterality in patients with ASD. F-18 fluorodeoxyglucose positron emission computed tomography (F-18 FDG PET/CT) is a neuroimaging technique that is suitable for ASD owing to its ability to detect whole brain functional abnormalities in a short time and is feasible in ASD patients. The purpose of this study was to evaluate brain laterality using F-18 FDG PET/CT in patients with high-functioning ASD. MATERIALS AND METHODS: This case-control study recruited eight ASD patients who met the DSM-5 criteria, the recorded data of eight controls matched for age, sex, and handedness were also enrolled. The resting state of brain glucose metabolism in the regions of interest (ROIs) was analyzed using the Q.Brain software. Brain glucose metabolism and laterality index in each ROI of ASD patients were compared with those of the controls. The pattern of brain metabolism was analyzed using visual analysis and is reported in the data description. RESULTS: The ASD group’s overall brain glucose metabolism was lower than that of the control group in both the left and right hemispheres, with mean differences of 1.54 and 1.21, respectively. We found statistically lower mean glucose metabolism for ASD patients than controls in the left prefrontal lateral (Z = 1.96, p = 0.049). The left laterality index was found in nine ROIs for ASD and 11 ROIs for the control. The left laterality index in the ASD group was significantly lower than that in the control group in the prefrontal lateral (Z = 2.52, p = 0.012), precuneus (Z = 2.10, p = 0.036), and parietal inferior (Z = 1.96, p = 0.049) regions. CONCLUSION: Individuals with ASD have lower brain glucose metabolism than control. In addition, the number of ROIs for left laterality index in the ASD group was lower than control. Left laterality defects may be one of the causes of ASD. This knowledge can be useful in the treatment of ASD by increasing the left-brain metabolism. This trial was registered in the Thai Clinical Trials Registry (TCTR20210705005). Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399910/ /pubmed/36034502 http://dx.doi.org/10.3389/fnmol.2022.901016 Text en Copyright © 2022 Keeratitanont, Theerakulpisut, Auvichayapat, Suphakunpinyo, Patjanasoontorn, Tiamkao, Tepmongkol, Khiewvan, Raruenrom, Srisuruk, Paholpak and Auvichayapat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Keeratitanont, Keattichai
Theerakulpisut, Daris
Auvichayapat, Narong
Suphakunpinyo, Chanyut
Patjanasoontorn, Niramol
Tiamkao, Somsak
Tepmongkol, Supatporn
Khiewvan, Benjapa
Raruenrom, Yutapong
Srisuruk, Piyawan
Paholpak, Suchat
Auvichayapat, Paradee
Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders
title Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders
title_full Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders
title_fullStr Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders
title_full_unstemmed Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders
title_short Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders
title_sort brain laterality evaluated by f-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399910/
https://www.ncbi.nlm.nih.gov/pubmed/36034502
http://dx.doi.org/10.3389/fnmol.2022.901016
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