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Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species

As the ornamental plants and traditional medicines, Rhododendron przewalskii, R. anthopogonoides, R. thymifolium, and R. capitatum are widely distributed in western China. In this paper, the essential oils from these four species were extracted by supercritical extraction and the components were ana...

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Autores principales: He, Jian, Shang, Xiaofei, Dai, Lixia, Yang, Xiaorong, Li, Bing, Wei, Yanming, Zhang, Jiyu, Pan, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399923/
https://www.ncbi.nlm.nih.gov/pubmed/36032278
http://dx.doi.org/10.3389/fvets.2022.882060
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author He, Jian
Shang, Xiaofei
Dai, Lixia
Yang, Xiaorong
Li, Bing
Wei, Yanming
Zhang, Jiyu
Pan, Hu
author_facet He, Jian
Shang, Xiaofei
Dai, Lixia
Yang, Xiaorong
Li, Bing
Wei, Yanming
Zhang, Jiyu
Pan, Hu
author_sort He, Jian
collection PubMed
description As the ornamental plants and traditional medicines, Rhododendron przewalskii, R. anthopogonoides, R. thymifolium, and R. capitatum are widely distributed in western China. In this paper, the essential oils from these four species were extracted by supercritical extraction and the components were analyzed using headspace solid phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME-GC-MS), the antibacterial, acaricidal and anti-inflammatory activities were investigated. Results showed that R. thymifolium (RTEO) contained the highest yield of 0.99% with 246 compounds, followed by R. capitatum (RCEO, 0.81%) with 290 chemicals, R. anthopogonoides (RAEO, 0.57%) with 302 compounds and R. przewalskii (RPEO, 0.30%) with 294 components. They also exhibited the safety at given doses and have the anti-inflammatory in vitro and in vivo tests via inhibiting the cytokines productions, the acaricidal and antibacterial activities also were found. 4-Hydroxy-3-methylacetophenone from RPEO, α-pinene and β-pinene from RAEO, β-farnesene and germacrone from RTEO, and benzylacetone from RCEO, as main and active components, inhibited the NO content in RAW 264.7 cells induced by LPS. These results indicated that four essential oils have certain medicinal value and laid the foundation for the development of these species as raw materials for the pharmaceutical and perfume industries.
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spelling pubmed-93999232022-08-25 Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species He, Jian Shang, Xiaofei Dai, Lixia Yang, Xiaorong Li, Bing Wei, Yanming Zhang, Jiyu Pan, Hu Front Vet Sci Veterinary Science As the ornamental plants and traditional medicines, Rhododendron przewalskii, R. anthopogonoides, R. thymifolium, and R. capitatum are widely distributed in western China. In this paper, the essential oils from these four species were extracted by supercritical extraction and the components were analyzed using headspace solid phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME-GC-MS), the antibacterial, acaricidal and anti-inflammatory activities were investigated. Results showed that R. thymifolium (RTEO) contained the highest yield of 0.99% with 246 compounds, followed by R. capitatum (RCEO, 0.81%) with 290 chemicals, R. anthopogonoides (RAEO, 0.57%) with 302 compounds and R. przewalskii (RPEO, 0.30%) with 294 components. They also exhibited the safety at given doses and have the anti-inflammatory in vitro and in vivo tests via inhibiting the cytokines productions, the acaricidal and antibacterial activities also were found. 4-Hydroxy-3-methylacetophenone from RPEO, α-pinene and β-pinene from RAEO, β-farnesene and germacrone from RTEO, and benzylacetone from RCEO, as main and active components, inhibited the NO content in RAW 264.7 cells induced by LPS. These results indicated that four essential oils have certain medicinal value and laid the foundation for the development of these species as raw materials for the pharmaceutical and perfume industries. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9399923/ /pubmed/36032278 http://dx.doi.org/10.3389/fvets.2022.882060 Text en Copyright © 2022 He, Shang, Dai, Yang, Li, Wei, Zhang and Pan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
He, Jian
Shang, Xiaofei
Dai, Lixia
Yang, Xiaorong
Li, Bing
Wei, Yanming
Zhang, Jiyu
Pan, Hu
Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species
title Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species
title_full Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species
title_fullStr Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species
title_full_unstemmed Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species
title_short Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species
title_sort chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four rhododendron species
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399923/
https://www.ncbi.nlm.nih.gov/pubmed/36032278
http://dx.doi.org/10.3389/fvets.2022.882060
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