Cargando…

Catalytic Mechanism of ATP Hydrolysis in the ATPase Domain of Human DNA Topoisomerase IIα

[Image: see text] Human DNA topoisomerase IIα is a biological nanomachine that regulates the topological changes of the DNA molecule and is considered a prime target for anticancer drugs. Despite intensive research, many atomic details about its mechanism of action remain unknown. We investigated th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ogrizek, Mitja, Janežič, Matej, Valjavec, Katja, Perdih, Andrej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400105/ https://www.ncbi.nlm.nih.gov/pubmed/35948041 http://dx.doi.org/10.1021/acs.jcim.2c00303

Ejemplares similares

Substituted 4,5′-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα
por: Bergant Loboda, Kaja, et al.
Publicado: (2020)

Dynophore-Based Approach in Virtual Screening: A Case of Human DNA Topoisomerase IIα
por: Janežič, Matej, et al.
Publicado: (2021)

Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle
por: Pavlin, Matic, et al.
Publicado: (2023)

Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα
por: Cvijetić, Ilija N., et al.
Publicado: (2023)

Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain
por: Clarke, Duncan J., et al.
Publicado: (2017)

The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks
por: Bates, Andrew D., et al.
Publicado: (2011)

Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase
por: Laponogov, Ivan, et al.
Publicado: (2018)

Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity
por: Dougherty, Ashley C., et al.
Publicado: (2021)

Role of magnesium ions in the reaction mechanism at the interface between Tm1631 protein and its DNA ligand
por: Ogrizek, Mitja, et al.
Publicado: (2016)

Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue
por: Chène, Patrick, et al.
Publicado: (2009)

Dissociation of clathrin coats coupled to the hydrolysis of ATP: role of an uncoating ATPase
Publicado: (1984)

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint
por: Kozuki, Toshiyuki, et al.
Publicado: (2017)

Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90
por: Jun, Kyu-Yeon, et al.
Publicado: (2016)

Design, Synthesis and Evaluation of Fused Bicyclo[2.2.2]octene as a Potential Core Scaffold for the Non-Covalent Inhibitors of SARS-CoV-2 3CL(pro) Main Protease
por: Herlah, Barbara, et al.
Publicado: (2022)

Structure-Based Function Prediction of Uncharacterized Protein Using Binding Sites Comparison
por: Konc, Janez, et al.
Publicado: (2013)

Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism
por: Lindsey, R. Hunter, et al.
Publicado: (2014)

mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity
por: Gilroy, Kathryn L., et al.
Publicado: (2006)

Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain
por: Bedez, Claire, et al.
Publicado: (2018)

Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus
por: Borišek, Jure, et al.
Publicado: (2018)

Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition
por: Ponder, Jessica, et al.
Publicado: (2011)

Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle
por: Jayakanthan, Samuel, et al.
Publicado: (2012)

Rotary mechanism of V/A-ATPases—how is ATP hydrolysis converted into a mechanical step rotation in rotary ATPases?
por: Yokoyama, Ken
Publicado: (2023)

ATP hydrolysis assists phosphate release and promotes reaction ordering in F(1)-ATPase
por: Li, Chun-Biu, et al.
Publicado: (2015)

RecA-like domain 2 of DNA-dependent ATPase A domain, a SWI2/SNF2 protein, mediates conformational integrity and ATP hydrolysis
por: Bansal, Ritu, et al.
Publicado: (2018)

HMGB1 interacts with human topoisomerase IIα and stimulates its catalytic activity
por: Štros, Michal, et al.
Publicado: (2007)

The Impact of the C-Terminal Domain on the Interaction of Human DNA Topoisomerase II α and β with DNA
por: Gilroy, Kathryn L., et al.
Publicado: (2011)

Ontogeny of ATP hydrolysis and isoform expression of the Plasma Membrane Ca(2+)-ATPase in mouse brain
por: Marcos, Daniel, et al.
Publicado: (2009)

Publisher Correction: Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain
por: Bedez, Claire, et al.
Publicado: (2018)

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193
por: Ling, Elise M., et al.
Publicado: (2022)

Lytic Water Dynamics Reveal Evolutionarily Conserved Mechanisms of ATP Hydrolysis by TIP49 AAA+ ATPases
por: Afanasyeva, Arina, et al.
Publicado: (2014)

Beyond binding change: the molecular mechanism of ATP hydrolysis by F(1)-ATPase and its biochemical consequences
por: Nath, Sunil
Publicado: (2023)

Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics
por: Matias-Barrios, Victor M., et al.
Publicado: (2021)

Natural Products as Topoisomerase II Poisons: Effects of Thymoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα
por: Ashley, Rachel E., et al.
Publicado: (2014)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
por: Grossman, Scott, et al.
Publicado: (2023)

N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion
Publicado: (1994)

Nucleotide-induced asymmetry within ATPase activator ring drives σ54–RNAP interaction and ATP hydrolysis
por: Sysoeva, Tatyana A., et al.
Publicado: (2013)

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin
por: Jong, R S de, et al.
Publicado: (1999)

Regulation of the catalytic function of topoisomerase II alpha through association with RNA
por: Park, Seung-Won, et al.
Publicado: (2008)

Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti-Cancer Therapy
por: Matias-Barrios, Victor M., et al.
Publicado: (2021)

Understanding ATP binding to DosS catalytic domain with a short ATP-lid
por: Larson, Grant, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_q7a5uplucvqq93tnr5prhhek9q