Cargando…

Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India

BACKGROUND: Hepatitis B virus infection is a global health priority, and health-care personnel (HCP) have 10 times higher prevalence than the general population. Seromonitoring identifies those with low titers and vaccine nonresponders with increased risk. OBJECTIVE: The objective of the study was t...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomas, Bina, Mohandas, Anu, Jayadev, V. K., Bindu, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400368/
https://www.ncbi.nlm.nih.gov/pubmed/36034260
http://dx.doi.org/10.4103/ijcm.ijcm_600_21
_version_ 1784772728196169728
author Thomas, Bina
Mohandas, Anu
Jayadev, V. K.
Bindu, V.
author_facet Thomas, Bina
Mohandas, Anu
Jayadev, V. K.
Bindu, V.
author_sort Thomas, Bina
collection PubMed
description BACKGROUND: Hepatitis B virus infection is a global health priority, and health-care personnel (HCP) have 10 times higher prevalence than the general population. Seromonitoring identifies those with low titers and vaccine nonresponders with increased risk. OBJECTIVE: The objective of the study was to assess hepatitis B surface antibody (anti-HBs) titers and associated factors among HCP vaccinated against hepatitis B in a teaching hospital in Kerala. METHODS: A cross-sectional study was done among 454 vaccinated HCP, and anti-HBs antibody titers were assessed by enzyme-linked immunosorbent assay method. RESULTS: Participants included 162 (35.7%) doctors, 132 (29.3%) nursing and laboratory personnel, and 160 (35.3%) supporting staff. The mean age was 38.06 ± 11.33 years, and 72% were female. Majority (92.5%, 420) were seroprotected and 78.9% (358) with high (>100 mIU) titers. Moderate (10–100 mIU) and low (<10 mIU) level seroprotection was seen in 13.7% (62) and 7.5% (34), respectively. Incomplete vaccination, >10 years since vaccination, and age >40 years were independent predictors for poor seroprotection, while increasing doses and boosters were positively associated. CONCLUSIONS: Majority of vaccinated HCP were seroprotected. Incomplete schedules, older age, and prolonged time since vaccination can lead to decline in titers, and periodical seromonitoring should guide hepatitis B revaccination strategies.
format Online
Article
Text
id pubmed-9400368
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-94003682022-08-25 Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India Thomas, Bina Mohandas, Anu Jayadev, V. K. Bindu, V. Indian J Community Med Short Communication BACKGROUND: Hepatitis B virus infection is a global health priority, and health-care personnel (HCP) have 10 times higher prevalence than the general population. Seromonitoring identifies those with low titers and vaccine nonresponders with increased risk. OBJECTIVE: The objective of the study was to assess hepatitis B surface antibody (anti-HBs) titers and associated factors among HCP vaccinated against hepatitis B in a teaching hospital in Kerala. METHODS: A cross-sectional study was done among 454 vaccinated HCP, and anti-HBs antibody titers were assessed by enzyme-linked immunosorbent assay method. RESULTS: Participants included 162 (35.7%) doctors, 132 (29.3%) nursing and laboratory personnel, and 160 (35.3%) supporting staff. The mean age was 38.06 ± 11.33 years, and 72% were female. Majority (92.5%, 420) were seroprotected and 78.9% (358) with high (>100 mIU) titers. Moderate (10–100 mIU) and low (<10 mIU) level seroprotection was seen in 13.7% (62) and 7.5% (34), respectively. Incomplete vaccination, >10 years since vaccination, and age >40 years were independent predictors for poor seroprotection, while increasing doses and boosters were positively associated. CONCLUSIONS: Majority of vaccinated HCP were seroprotected. Incomplete schedules, older age, and prolonged time since vaccination can lead to decline in titers, and periodical seromonitoring should guide hepatitis B revaccination strategies. Wolters Kluwer - Medknow 2022 2022-07-11 /pmc/articles/PMC9400368/ /pubmed/36034260 http://dx.doi.org/10.4103/ijcm.ijcm_600_21 Text en Copyright: © 2022 Indian Journal of Community Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Short Communication
Thomas, Bina
Mohandas, Anu
Jayadev, V. K.
Bindu, V.
Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India
title Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India
title_full Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India
title_fullStr Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India
title_full_unstemmed Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India
title_short Hepatitis B Surface Antibody Levels among Health-Care Personnel Vaccinated against Hepatitis B in a Teaching Hospital in South India
title_sort hepatitis b surface antibody levels among health-care personnel vaccinated against hepatitis b in a teaching hospital in south india
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400368/
https://www.ncbi.nlm.nih.gov/pubmed/36034260
http://dx.doi.org/10.4103/ijcm.ijcm_600_21
work_keys_str_mv AT thomasbina hepatitisbsurfaceantibodylevelsamonghealthcarepersonnelvaccinatedagainsthepatitisbinateachinghospitalinsouthindia
AT mohandasanu hepatitisbsurfaceantibodylevelsamonghealthcarepersonnelvaccinatedagainsthepatitisbinateachinghospitalinsouthindia
AT jayadevvk hepatitisbsurfaceantibodylevelsamonghealthcarepersonnelvaccinatedagainsthepatitisbinateachinghospitalinsouthindia
AT binduv hepatitisbsurfaceantibodylevelsamonghealthcarepersonnelvaccinatedagainsthepatitisbinateachinghospitalinsouthindia