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Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context
BACKGROUND: Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. METHODS: Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharg...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400424/ https://www.ncbi.nlm.nih.gov/pubmed/35176762 http://dx.doi.org/10.1093/infdis/jiac057 |
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| author | Nkuba-Ndaye, Antoine Mukadi-Bamuleka, Daniel Bulabula-Penge, Junior Thaurignac, Guillaume Edidi-Atani, François Mambu-Mbika, Fabrice Danga-Yema, Bernice Matondo-Kuamfumu, Meris Kinganda-Lusamaki, Eddy Bisento, Nella Lumembe-Numbi, Raphaël Kabamba-Lungenyi, Gabriel Kitsa-Mutsumbirwa, Divine Kambale-Sivihwa, Nelson Boillot, François Delaporte, Eric Mbala-Kingebeni, Placide Ayouba, Ahidjo Peeters, Martine Ahuka-Mundeke, Steve |
| author_facet | Nkuba-Ndaye, Antoine Mukadi-Bamuleka, Daniel Bulabula-Penge, Junior Thaurignac, Guillaume Edidi-Atani, François Mambu-Mbika, Fabrice Danga-Yema, Bernice Matondo-Kuamfumu, Meris Kinganda-Lusamaki, Eddy Bisento, Nella Lumembe-Numbi, Raphaël Kabamba-Lungenyi, Gabriel Kitsa-Mutsumbirwa, Divine Kambale-Sivihwa, Nelson Boillot, François Delaporte, Eric Mbala-Kingebeni, Placide Ayouba, Ahidjo Peeters, Martine Ahuka-Mundeke, Steve |
| author_sort | Nkuba-Ndaye, Antoine |
| collection | PubMed |
| description | BACKGROUND: Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. METHODS: Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo. RESULTS: After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases. CONCLUSIONS: These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative. |
| format | Online Article Text |
| id | pubmed-9400424 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94004242022-08-25 Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context Nkuba-Ndaye, Antoine Mukadi-Bamuleka, Daniel Bulabula-Penge, Junior Thaurignac, Guillaume Edidi-Atani, François Mambu-Mbika, Fabrice Danga-Yema, Bernice Matondo-Kuamfumu, Meris Kinganda-Lusamaki, Eddy Bisento, Nella Lumembe-Numbi, Raphaël Kabamba-Lungenyi, Gabriel Kitsa-Mutsumbirwa, Divine Kambale-Sivihwa, Nelson Boillot, François Delaporte, Eric Mbala-Kingebeni, Placide Ayouba, Ahidjo Peeters, Martine Ahuka-Mundeke, Steve J Infect Dis Brief Report BACKGROUND: Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. METHODS: Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo. RESULTS: After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases. CONCLUSIONS: These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative. Oxford University Press 2022-02-18 /pmc/articles/PMC9400424/ /pubmed/35176762 http://dx.doi.org/10.1093/infdis/jiac057 Text en © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Nkuba-Ndaye, Antoine Mukadi-Bamuleka, Daniel Bulabula-Penge, Junior Thaurignac, Guillaume Edidi-Atani, François Mambu-Mbika, Fabrice Danga-Yema, Bernice Matondo-Kuamfumu, Meris Kinganda-Lusamaki, Eddy Bisento, Nella Lumembe-Numbi, Raphaël Kabamba-Lungenyi, Gabriel Kitsa-Mutsumbirwa, Divine Kambale-Sivihwa, Nelson Boillot, François Delaporte, Eric Mbala-Kingebeni, Placide Ayouba, Ahidjo Peeters, Martine Ahuka-Mundeke, Steve Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context |
| title | Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context |
| title_full | Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context |
| title_fullStr | Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context |
| title_full_unstemmed | Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context |
| title_short | Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context |
| title_sort | added value of an anti-ebola serology for the management of clinically suspected ebola virus disease patients discharged as negative in an epidemic context |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400424/ https://www.ncbi.nlm.nih.gov/pubmed/35176762 http://dx.doi.org/10.1093/infdis/jiac057 |
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