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Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats

BACKGROUND AND PURPOSE: Medicinal plants have been used to cure numerous diseases compared to orthodox medicines. The present study estimated the antidiabetic activity of ethanolic extract of Salvia tebesana Bunge in streptozotocin-induced diabetic rats. EXPERIMENTAL APPROACH: In this study type 2 d...

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Autores principales: Aramjoo, Hamed, Kiani, Zahra, Eghbali, Samira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400469/
https://www.ncbi.nlm.nih.gov/pubmed/36034081
http://dx.doi.org/10.4103/1735-5362.350241
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author Aramjoo, Hamed
Kiani, Zahra
Eghbali, Samira
author_facet Aramjoo, Hamed
Kiani, Zahra
Eghbali, Samira
author_sort Aramjoo, Hamed
collection PubMed
description BACKGROUND AND PURPOSE: Medicinal plants have been used to cure numerous diseases compared to orthodox medicines. The present study estimated the antidiabetic activity of ethanolic extract of Salvia tebesana Bunge in streptozotocin-induced diabetic rats. EXPERIMENTAL APPROACH: In this study type 2 diabetes was induced in male rats by streptozotocin (65 mg/kg, i.p.). After diabetes induction, normal control groups were treated with distilled water, the positive control group received metformin (500 mg/kg), and the other groups were orally treated with ethanolic extracts of S. tebesana (100, 200, and 400 mg/kg) for 4 weeks. Changes in body weight and some biochemical parameters were determined. FINDINGS / RESULTS: The ethanolic extract of S. tebesana in all doses considerably declined serum glucose, total cholesterol, alanine aminotransferase, aspartate aminotransferase, and triglyceride compared with the diabetic control rats. Administration of ethanolic extract of S. tebesana reduced the serum of kidney and liver function factors and decreased the side effects on the function of these. CONCLUSION AND IMPLICATIONS: These results revealed the potential of S. tebesana for the cure of diabetes and its problems.
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spelling pubmed-94004692022-08-25 Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats Aramjoo, Hamed Kiani, Zahra Eghbali, Samira Res Pharm Sci Original Article BACKGROUND AND PURPOSE: Medicinal plants have been used to cure numerous diseases compared to orthodox medicines. The present study estimated the antidiabetic activity of ethanolic extract of Salvia tebesana Bunge in streptozotocin-induced diabetic rats. EXPERIMENTAL APPROACH: In this study type 2 diabetes was induced in male rats by streptozotocin (65 mg/kg, i.p.). After diabetes induction, normal control groups were treated with distilled water, the positive control group received metformin (500 mg/kg), and the other groups were orally treated with ethanolic extracts of S. tebesana (100, 200, and 400 mg/kg) for 4 weeks. Changes in body weight and some biochemical parameters were determined. FINDINGS / RESULTS: The ethanolic extract of S. tebesana in all doses considerably declined serum glucose, total cholesterol, alanine aminotransferase, aspartate aminotransferase, and triglyceride compared with the diabetic control rats. Administration of ethanolic extract of S. tebesana reduced the serum of kidney and liver function factors and decreased the side effects on the function of these. CONCLUSION AND IMPLICATIONS: These results revealed the potential of S. tebesana for the cure of diabetes and its problems. Wolters Kluwer - Medknow 2022-07-14 /pmc/articles/PMC9400469/ /pubmed/36034081 http://dx.doi.org/10.4103/1735-5362.350241 Text en Copyright: © 2022 Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Aramjoo, Hamed
Kiani, Zahra
Eghbali, Samira
Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats
title Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats
title_full Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats
title_fullStr Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats
title_full_unstemmed Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats
title_short Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats
title_sort antihyperglycemic and hepatoprotective effects of salvia tebesana bunge in diabetic rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400469/
https://www.ncbi.nlm.nih.gov/pubmed/36034081
http://dx.doi.org/10.4103/1735-5362.350241
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