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The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome Replication

Positive-strand RNA viruses replicate their genomes using virally encoded RNA-dependent RNA polymerases (RdRP) with a common active-site structure and closure mechanism upon which replication speed and fidelity can evolve to optimize virus fitness. Coronaviruses (CoV) form large multicomponent RNA r...

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Detalles Bibliográficos
Autores principales:	Campagnola, Grace, Govindarajan, Vishnu, Pelletier, Annelise, Canard, Bruno, Peersen, Olve B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400494/ https://www.ncbi.nlm.nih.gov/pubmed/35924919 http://dx.doi.org/10.1128/jvi.00671-22

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