Cargando…

Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2

BACKGROUND: Breast Implant Illness (BII), as described in recent medical literature and by social media, describes a range of symptoms in patients with breast implants for which there are no physical findings or laboratory results that explain their symptoms. OBJECTIVES: Part 2 of this study aims to...

Descripción completa

Detalles Bibliográficos
Autores principales: Wixtrom, Roger, Glicksman, Caroline, Kadin, Marshall, Lawrence, Marisa, Haws, Melinda, Ferenz, Sarah, Sung, James, McGuire, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400612/
https://www.ncbi.nlm.nih.gov/pubmed/35474526
http://dx.doi.org/10.1093/asj/sjac106
_version_ 1784772779678105600
author Wixtrom, Roger
Glicksman, Caroline
Kadin, Marshall
Lawrence, Marisa
Haws, Melinda
Ferenz, Sarah
Sung, James
McGuire, Patricia
author_facet Wixtrom, Roger
Glicksman, Caroline
Kadin, Marshall
Lawrence, Marisa
Haws, Melinda
Ferenz, Sarah
Sung, James
McGuire, Patricia
author_sort Wixtrom, Roger
collection PubMed
description BACKGROUND: Breast Implant Illness (BII), as described in recent medical literature and by social media, describes a range of symptoms in patients with breast implants for which there are no physical findings or laboratory results that explain their symptoms. OBJECTIVES: Part 2 of this study aims to determine whether heavy metals are present in the capsules around saline and silicone implants and if there are statistical differences in the type or level of these metals between women with or without symptoms. Demographic data was collected to investigate potential alternate sources of metals: inhaled, absorbed, or ingested. METHODS: A prospective, blinded study enrolled 150 consecutive subjects divided equally into in three cohorts: (A) women with systemic symptoms they attribute to their implants who requested implant removal, (B) women with breast implants requesting removal or exchange who do not have symptoms they attribute to their implants, and (C) women undergoing cosmetic mastopexy who have never had any implanted medical device. Capsule tissue was removed from Cohort A and B for analysis of 22 heavy metals. Additionally, breast tissue was obtained from a control group with no previous exposure to any implanted medical device. RESULTS: The study was performed between 2019-2021. Heavy metal content was compared between the capsule tissue from Cohort A and B. The only statistically significant differences identified in Cohort A were higher levels of arsenic and zinc, and lower levels of cobalt, manganese, silver, and tin. There were no elevated levels or statistically significant differences in the other metals tested between Cohorts A and B. CONCLUSIONS: This study analyzes the metal content in capsules surrounding both saline and silicone breast implants. Heavy metals were also detected in the non-implant control group breast tissue, with some metals at numerically higher levels than either breast implant cohort. Smoking, gluten free diets, dietary supplements, and the presence of tattoos were all identified as statistically significant sources of arsenic and zinc in Cohort A. The risk of heavy metal toxicity should not be used as an indication for total capsulectomy if patients elect to remove their breast implants. LEVEL OF EVIDENCE: 3: [Image: see text]
format Online
Article
Text
id pubmed-9400612
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-94006122022-08-25 Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2 Wixtrom, Roger Glicksman, Caroline Kadin, Marshall Lawrence, Marisa Haws, Melinda Ferenz, Sarah Sung, James McGuire, Patricia Aesthet Surg J Research BACKGROUND: Breast Implant Illness (BII), as described in recent medical literature and by social media, describes a range of symptoms in patients with breast implants for which there are no physical findings or laboratory results that explain their symptoms. OBJECTIVES: Part 2 of this study aims to determine whether heavy metals are present in the capsules around saline and silicone implants and if there are statistical differences in the type or level of these metals between women with or without symptoms. Demographic data was collected to investigate potential alternate sources of metals: inhaled, absorbed, or ingested. METHODS: A prospective, blinded study enrolled 150 consecutive subjects divided equally into in three cohorts: (A) women with systemic symptoms they attribute to their implants who requested implant removal, (B) women with breast implants requesting removal or exchange who do not have symptoms they attribute to their implants, and (C) women undergoing cosmetic mastopexy who have never had any implanted medical device. Capsule tissue was removed from Cohort A and B for analysis of 22 heavy metals. Additionally, breast tissue was obtained from a control group with no previous exposure to any implanted medical device. RESULTS: The study was performed between 2019-2021. Heavy metal content was compared between the capsule tissue from Cohort A and B. The only statistically significant differences identified in Cohort A were higher levels of arsenic and zinc, and lower levels of cobalt, manganese, silver, and tin. There were no elevated levels or statistically significant differences in the other metals tested between Cohorts A and B. CONCLUSIONS: This study analyzes the metal content in capsules surrounding both saline and silicone breast implants. Heavy metals were also detected in the non-implant control group breast tissue, with some metals at numerically higher levels than either breast implant cohort. Smoking, gluten free diets, dietary supplements, and the presence of tattoos were all identified as statistically significant sources of arsenic and zinc in Cohort A. The risk of heavy metal toxicity should not be used as an indication for total capsulectomy if patients elect to remove their breast implants. LEVEL OF EVIDENCE: 3: [Image: see text] Oxford University Press 2022-04-26 /pmc/articles/PMC9400612/ /pubmed/35474526 http://dx.doi.org/10.1093/asj/sjac106 Text en © 2022 The Aesthetic Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research
Wixtrom, Roger
Glicksman, Caroline
Kadin, Marshall
Lawrence, Marisa
Haws, Melinda
Ferenz, Sarah
Sung, James
McGuire, Patricia
Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2
title Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2
title_full Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2
title_fullStr Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2
title_full_unstemmed Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2
title_short Heavy Metals in Breast Implant Capsules and Breast Tissue: Findings from the Systemic Symptoms in Women–Biospecimen Analysis Study: Part 2
title_sort heavy metals in breast implant capsules and breast tissue: findings from the systemic symptoms in women–biospecimen analysis study: part 2
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400612/
https://www.ncbi.nlm.nih.gov/pubmed/35474526
http://dx.doi.org/10.1093/asj/sjac106
work_keys_str_mv AT wixtromroger heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2
AT glicksmancaroline heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2
AT kadinmarshall heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2
AT lawrencemarisa heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2
AT hawsmelinda heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2
AT ferenzsarah heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2
AT sungjames heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2
AT mcguirepatricia heavymetalsinbreastimplantcapsulesandbreasttissuefindingsfromthesystemicsymptomsinwomenbiospecimenanalysisstudypart2