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Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer

Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strate...

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Autores principales: Girisa, Sosmitha, Parama, Dey, Harsha, Choudhary, Banik, Kishore, Kunnumakkara, Ajaikumar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400725/
https://www.ncbi.nlm.nih.gov/pubmed/36046484
http://dx.doi.org/10.37349/etat.2020.00019
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author Girisa, Sosmitha
Parama, Dey
Harsha, Choudhary
Banik, Kishore
Kunnumakkara, Ajaikumar B.
author_facet Girisa, Sosmitha
Parama, Dey
Harsha, Choudhary
Banik, Kishore
Kunnumakkara, Ajaikumar B.
author_sort Girisa, Sosmitha
collection PubMed
description Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine. This plant has diverse pharmacological properties such as antioxidant, antibacterial, antimutagenic, and antitumor which mostly owes to the presence of its active compound guggulsterone (GS) that exists in the form of Z- and E-isomers. Mounting evidence suggests that this compound has promising anticancer activities and was shown to suppress several cancer signaling pathways such as NF-κB/ERK/MAPK/AKT/STAT and modulate the expression of numerous signaling molecules such as the farnesoid X receptor, cyclin D1, survivin, caspases, HIF-1α, MMP-9, EMT proteins, tumor suppressor proteins, angiogenic proteins, and apoptotic proteins. The current review is an attempt to summarize the biological activities and diverse anticancer activities (both in vitro and in vivo) of the compound GS and its derivatives, along with its associated mechanism against various cancers.
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spelling pubmed-94007252022-08-30 Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer Girisa, Sosmitha Parama, Dey Harsha, Choudhary Banik, Kishore Kunnumakkara, Ajaikumar B. Explor Target Antitumor Ther Review Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one such plant which has been used to cure various ailments in traditional systems of medicine. This plant has diverse pharmacological properties such as antioxidant, antibacterial, antimutagenic, and antitumor which mostly owes to the presence of its active compound guggulsterone (GS) that exists in the form of Z- and E-isomers. Mounting evidence suggests that this compound has promising anticancer activities and was shown to suppress several cancer signaling pathways such as NF-κB/ERK/MAPK/AKT/STAT and modulate the expression of numerous signaling molecules such as the farnesoid X receptor, cyclin D1, survivin, caspases, HIF-1α, MMP-9, EMT proteins, tumor suppressor proteins, angiogenic proteins, and apoptotic proteins. The current review is an attempt to summarize the biological activities and diverse anticancer activities (both in vitro and in vivo) of the compound GS and its derivatives, along with its associated mechanism against various cancers. Open Exploration 2020 2020-10-30 /pmc/articles/PMC9400725/ /pubmed/36046484 http://dx.doi.org/10.37349/etat.2020.00019 Text en © The Author(s) 2020. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Girisa, Sosmitha
Parama, Dey
Harsha, Choudhary
Banik, Kishore
Kunnumakkara, Ajaikumar B.
Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
title Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
title_full Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
title_fullStr Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
title_full_unstemmed Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
title_short Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
title_sort potential of guggulsterone, a farnesoid x receptor antagonist, in the prevention and treatment of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400725/
https://www.ncbi.nlm.nih.gov/pubmed/36046484
http://dx.doi.org/10.37349/etat.2020.00019
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