Current strategies for the design of PROTAC linkers: a critical review

PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands; an “anchor” to bind to an E3 ubiquitin ligase and a “warhead” to bind to a protein of interest, connected by a chemical linker. Targeted protein degradation by PROTACs has emerged as a new modality f...

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Detalles Bibliográficos
Autores principales: Troup, Robert I., Fallan, Charlene, Baud, Matthias G. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400730/
https://www.ncbi.nlm.nih.gov/pubmed/36046485
http://dx.doi.org/10.37349/etat.2020.00018

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