Circulating biomarkers in malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is an aggressive tumor strictly connected to asbestos exposure. Prognosis is dismal as diagnosis commonly occurs in advanced stage. Radiological screenings have not proven to be effective and also pathological diagnosis may be challenging. In the era of precision...

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Autores principales: Viscardi, Giuseppe, Di Natale, Davide, Fasano, Morena, Brambilla, Marta, Lobefaro, Riccardo, De Toma, Alessandro, Galli, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400735/
https://www.ncbi.nlm.nih.gov/pubmed/36046389
http://dx.doi.org/10.37349/etat.2020.00028
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author Viscardi, Giuseppe
Di Natale, Davide
Fasano, Morena
Brambilla, Marta
Lobefaro, Riccardo
De Toma, Alessandro
Galli, Giulia
author_facet Viscardi, Giuseppe
Di Natale, Davide
Fasano, Morena
Brambilla, Marta
Lobefaro, Riccardo
De Toma, Alessandro
Galli, Giulia
author_sort Viscardi, Giuseppe
collection PubMed
description Malignant pleural mesothelioma (MPM) is an aggressive tumor strictly connected to asbestos exposure. Prognosis is dismal as diagnosis commonly occurs in advanced stage. Radiological screenings have not proven to be effective and also pathological diagnosis may be challenging. In the era of precision oncology, validation of robust non-invasive biomarkers for screening of asbestos-exposed individuals, assessment of prognosis and prediction of response to treatments remains an important unmet clinical need. This review provides an overview on current understanding and possible applications of liquid biopsy in MPM, mostly focused on the utility as diagnostic and prognostic test.
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spelling pubmed-94007352022-08-30 Circulating biomarkers in malignant pleural mesothelioma Viscardi, Giuseppe Di Natale, Davide Fasano, Morena Brambilla, Marta Lobefaro, Riccardo De Toma, Alessandro Galli, Giulia Explor Target Antitumor Ther Review Malignant pleural mesothelioma (MPM) is an aggressive tumor strictly connected to asbestos exposure. Prognosis is dismal as diagnosis commonly occurs in advanced stage. Radiological screenings have not proven to be effective and also pathological diagnosis may be challenging. In the era of precision oncology, validation of robust non-invasive biomarkers for screening of asbestos-exposed individuals, assessment of prognosis and prediction of response to treatments remains an important unmet clinical need. This review provides an overview on current understanding and possible applications of liquid biopsy in MPM, mostly focused on the utility as diagnostic and prognostic test. Open Exploration 2020 2020-12-28 /pmc/articles/PMC9400735/ /pubmed/36046389 http://dx.doi.org/10.37349/etat.2020.00028 Text en © The Author(s) 2020. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Viscardi, Giuseppe
Di Natale, Davide
Fasano, Morena
Brambilla, Marta
Lobefaro, Riccardo
De Toma, Alessandro
Galli, Giulia
Circulating biomarkers in malignant pleural mesothelioma
title Circulating biomarkers in malignant pleural mesothelioma
title_full Circulating biomarkers in malignant pleural mesothelioma
title_fullStr Circulating biomarkers in malignant pleural mesothelioma
title_full_unstemmed Circulating biomarkers in malignant pleural mesothelioma
title_short Circulating biomarkers in malignant pleural mesothelioma
title_sort circulating biomarkers in malignant pleural mesothelioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400735/
https://www.ncbi.nlm.nih.gov/pubmed/36046389
http://dx.doi.org/10.37349/etat.2020.00028
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