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Emerging role of pioneer transcription factors in targeted ERα positive breast cancer

Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer factors” are an emerging class of TFs that specifically interact with nucleosomal DNA and facilitate accessible genomi...

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Detalles Bibliográficos
Autores principales: Pavithran, Honey, Kumavath, Ranjith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400756/
https://www.ncbi.nlm.nih.gov/pubmed/36046086
http://dx.doi.org/10.37349/etat.2021.00031
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author Pavithran, Honey
Kumavath, Ranjith
author_facet Pavithran, Honey
Kumavath, Ranjith
author_sort Pavithran, Honey
collection PubMed
description Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer factors” are an emerging class of TFs that specifically interact with nucleosomal DNA and facilitate accessible genomic binding sites for the additional TFs. There is growing evidence of these specialized modulators in particular malignancies, as highlighted by agents’ clinical efficacy, specifically targeting nuclear hormone receptors. They have been implicated in multiple cancers more recently, with a high proportion inculpating on hormone influential cancers. Moreover, extended crosstalk and cooperation between ERα pioneering factors in estrogen-dependent breast cancer (BC) remain elucidated. This review discusses on the recent advances in our understanding of pioneer TFs in cancer, especially highlighting its potentiality to modulate chromatin condensation to permit ERα recruitment in BC cells. Through the study it was concluded that the highly prospected pioneer TFs in BC, including FOXA1, TLE1, PBX1, and GATA3, possess the potential therapeutic significance and further innovations in the field could yield targeted therapy in cancer treatment.
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spelling pubmed-94007562022-08-30 Emerging role of pioneer transcription factors in targeted ERα positive breast cancer Pavithran, Honey Kumavath, Ranjith Explor Target Antitumor Ther Review Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer factors” are an emerging class of TFs that specifically interact with nucleosomal DNA and facilitate accessible genomic binding sites for the additional TFs. There is growing evidence of these specialized modulators in particular malignancies, as highlighted by agents’ clinical efficacy, specifically targeting nuclear hormone receptors. They have been implicated in multiple cancers more recently, with a high proportion inculpating on hormone influential cancers. Moreover, extended crosstalk and cooperation between ERα pioneering factors in estrogen-dependent breast cancer (BC) remain elucidated. This review discusses on the recent advances in our understanding of pioneer TFs in cancer, especially highlighting its potentiality to modulate chromatin condensation to permit ERα recruitment in BC cells. Through the study it was concluded that the highly prospected pioneer TFs in BC, including FOXA1, TLE1, PBX1, and GATA3, possess the potential therapeutic significance and further innovations in the field could yield targeted therapy in cancer treatment. Open Exploration 2021 2021-02-28 /pmc/articles/PMC9400756/ /pubmed/36046086 http://dx.doi.org/10.37349/etat.2021.00031 Text en © The Author(s) 2021. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Pavithran, Honey
Kumavath, Ranjith
Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
title Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
title_full Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
title_fullStr Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
title_full_unstemmed Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
title_short Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
title_sort emerging role of pioneer transcription factors in targeted erα positive breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400756/
https://www.ncbi.nlm.nih.gov/pubmed/36046086
http://dx.doi.org/10.37349/etat.2021.00031
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