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Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-h...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Open Exploration
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400787/ https://www.ncbi.nlm.nih.gov/pubmed/36046358 http://dx.doi.org/10.37349/etat.2022.00073 |
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author | Stoyanova, Radoslava Kopf, Helmut Schima, Wolfgang Matzek, Wolfgang Karl Klaus, Alexander |
author_facet | Stoyanova, Radoslava Kopf, Helmut Schima, Wolfgang Matzek, Wolfgang Karl Klaus, Alexander |
author_sort | Stoyanova, Radoslava |
collection | PubMed |
description | Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-hepatectomy liver failure (PHLF) due to insufficient liver remnant remains the most dreaded complication with a negative effect on overall survival. Precise preoperative management with sufficient future remnant liver (FRL) volume is the key to achieving good results in the treatment of bile duct carcinoma. To present a case report and a literature review for preoperative FRL optimization prior to major hepatectomies for hilar cholangiocarcinoma. Improvement of postoperative outcomes after extended liver resections in the case of hilar cholangiocarcinoma. A 62-year-old Caucasian woman with Lynch syndrome presented to our department with a hilar cholangiocarcinoma Bismuth type IIIa. The patient had an insufficient future liver volume for extended liver resection. She underwent preoperative preconditioning using a liver venous deprivation (LVD) and underwent two weeks later a right trisectorectomy without any interventional complications. Liver function remained stable postoperatively. The patient was discharged on the 20th postoperative day without major surgical post-operative complications or the need for readmission. LVD is a technically feasible, safe, and effective procedure to increase the FRL in a short period of time with low intra and post-operative complications and therefore improving the survival of patients with hilar cholangiocarcinoma. |
format | Online Article Text |
id | pubmed-9400787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Open Exploration |
record_format | MEDLINE/PubMed |
spelling | pubmed-94007872022-08-30 Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature Stoyanova, Radoslava Kopf, Helmut Schima, Wolfgang Matzek, Wolfgang Karl Klaus, Alexander Explor Target Antitumor Ther Case Report Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-hepatectomy liver failure (PHLF) due to insufficient liver remnant remains the most dreaded complication with a negative effect on overall survival. Precise preoperative management with sufficient future remnant liver (FRL) volume is the key to achieving good results in the treatment of bile duct carcinoma. To present a case report and a literature review for preoperative FRL optimization prior to major hepatectomies for hilar cholangiocarcinoma. Improvement of postoperative outcomes after extended liver resections in the case of hilar cholangiocarcinoma. A 62-year-old Caucasian woman with Lynch syndrome presented to our department with a hilar cholangiocarcinoma Bismuth type IIIa. The patient had an insufficient future liver volume for extended liver resection. She underwent preoperative preconditioning using a liver venous deprivation (LVD) and underwent two weeks later a right trisectorectomy without any interventional complications. Liver function remained stable postoperatively. The patient was discharged on the 20th postoperative day without major surgical post-operative complications or the need for readmission. LVD is a technically feasible, safe, and effective procedure to increase the FRL in a short period of time with low intra and post-operative complications and therefore improving the survival of patients with hilar cholangiocarcinoma. Open Exploration 2022 2022-02-28 /pmc/articles/PMC9400787/ /pubmed/36046358 http://dx.doi.org/10.37349/etat.2022.00073 Text en © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Stoyanova, Radoslava Kopf, Helmut Schima, Wolfgang Matzek, Wolfgang Karl Klaus, Alexander Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature |
title | Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature |
title_full | Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature |
title_fullStr | Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature |
title_full_unstemmed | Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature |
title_short | Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature |
title_sort | liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400787/ https://www.ncbi.nlm.nih.gov/pubmed/36046358 http://dx.doi.org/10.37349/etat.2022.00073 |
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