Cargando…

Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature

Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-h...

Descripción completa

Detalles Bibliográficos
Autores principales: Stoyanova, Radoslava, Kopf, Helmut, Schima, Wolfgang, Matzek, Wolfgang Karl, Klaus, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400787/
https://www.ncbi.nlm.nih.gov/pubmed/36046358
http://dx.doi.org/10.37349/etat.2022.00073
_version_ 1784772818640044032
author Stoyanova, Radoslava
Kopf, Helmut
Schima, Wolfgang
Matzek, Wolfgang Karl
Klaus, Alexander
author_facet Stoyanova, Radoslava
Kopf, Helmut
Schima, Wolfgang
Matzek, Wolfgang Karl
Klaus, Alexander
author_sort Stoyanova, Radoslava
collection PubMed
description Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-hepatectomy liver failure (PHLF) due to insufficient liver remnant remains the most dreaded complication with a negative effect on overall survival. Precise preoperative management with sufficient future remnant liver (FRL) volume is the key to achieving good results in the treatment of bile duct carcinoma. To present a case report and a literature review for preoperative FRL optimization prior to major hepatectomies for hilar cholangiocarcinoma. Improvement of postoperative outcomes after extended liver resections in the case of hilar cholangiocarcinoma. A 62-year-old Caucasian woman with Lynch syndrome presented to our department with a hilar cholangiocarcinoma Bismuth type IIIa. The patient had an insufficient future liver volume for extended liver resection. She underwent preoperative preconditioning using a liver venous deprivation (LVD) and underwent two weeks later a right trisectorectomy without any interventional complications. Liver function remained stable postoperatively. The patient was discharged on the 20th postoperative day without major surgical post-operative complications or the need for readmission. LVD is a technically feasible, safe, and effective procedure to increase the FRL in a short period of time with low intra and post-operative complications and therefore improving the survival of patients with hilar cholangiocarcinoma.
format Online
Article
Text
id pubmed-9400787
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Open Exploration
record_format MEDLINE/PubMed
spelling pubmed-94007872022-08-30 Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature Stoyanova, Radoslava Kopf, Helmut Schima, Wolfgang Matzek, Wolfgang Karl Klaus, Alexander Explor Target Antitumor Ther Case Report Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-hepatectomy liver failure (PHLF) due to insufficient liver remnant remains the most dreaded complication with a negative effect on overall survival. Precise preoperative management with sufficient future remnant liver (FRL) volume is the key to achieving good results in the treatment of bile duct carcinoma. To present a case report and a literature review for preoperative FRL optimization prior to major hepatectomies for hilar cholangiocarcinoma. Improvement of postoperative outcomes after extended liver resections in the case of hilar cholangiocarcinoma. A 62-year-old Caucasian woman with Lynch syndrome presented to our department with a hilar cholangiocarcinoma Bismuth type IIIa. The patient had an insufficient future liver volume for extended liver resection. She underwent preoperative preconditioning using a liver venous deprivation (LVD) and underwent two weeks later a right trisectorectomy without any interventional complications. Liver function remained stable postoperatively. The patient was discharged on the 20th postoperative day without major surgical post-operative complications or the need for readmission. LVD is a technically feasible, safe, and effective procedure to increase the FRL in a short period of time with low intra and post-operative complications and therefore improving the survival of patients with hilar cholangiocarcinoma. Open Exploration 2022 2022-02-28 /pmc/articles/PMC9400787/ /pubmed/36046358 http://dx.doi.org/10.37349/etat.2022.00073 Text en © The Author(s) 2022. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Stoyanova, Radoslava
Kopf, Helmut
Schima, Wolfgang
Matzek, Wolfgang Karl
Klaus, Alexander
Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
title Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
title_full Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
title_fullStr Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
title_full_unstemmed Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
title_short Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
title_sort liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400787/
https://www.ncbi.nlm.nih.gov/pubmed/36046358
http://dx.doi.org/10.37349/etat.2022.00073
work_keys_str_mv AT stoyanovaradoslava livervenousdeprivationforresectionofadvancedhilarcholangiocarcinomaacasereportandreviewoftheliterature
AT kopfhelmut livervenousdeprivationforresectionofadvancedhilarcholangiocarcinomaacasereportandreviewoftheliterature
AT schimawolfgang livervenousdeprivationforresectionofadvancedhilarcholangiocarcinomaacasereportandreviewoftheliterature
AT matzekwolfgangkarl livervenousdeprivationforresectionofadvancedhilarcholangiocarcinomaacasereportandreviewoftheliterature
AT klausalexander livervenousdeprivationforresectionofadvancedhilarcholangiocarcinomaacasereportandreviewoftheliterature